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Amsterdam institute for Infection and Immunity

Amsterdam institute for Infection and Immunity

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Research highlights

ARCAID - Amsterdam Rheumatology Center for AutoImmune Diseases
ARCAID - Amsterdam Rheumatology Center for AutoImmune Diseases

ARCAID allows us to bring together 20 of the most talented young researchers in biomedicine from all over the world with top translational scientists.

Ongoing
Database
Database

The purpose of our database is that the researchers of AII can find each other based on name, research topic, technology, disease etc. The database is only accessible for the researchers of the AII.

Completed
Germline biomarkers of melanoma immunotherapy: an international consortium
Germline biomarkers of melanoma immunotherapy: an international consortium

Biomarkers that predict immunotherapy treatment success or risk of toxicity are urgently needed, to increase clinical benefit of metastatic melanoma patients.

Ongoing
IMI ImmuneImage
IMI ImmuneImage

The objective of Immune-Image is to develop a novel non-invasive imaging strategy for assessing immune cell activation and dynamics.

Ongoing
Lyme borreliosis: diagnosis and management

Chronic symptoms attributed to Lyme borreliosis can be challenging to diagnose and treat. This state of the art and systematic review in the BMJ by Kullberg and collaborators offers a roadmap for physicians how to provide the best possible and personalised care for their patients.

Ongoing
Pharmacokinetic and pharmacodynamic target attainment of antibiotics in different patient populations
Pharmacokinetic and pharmacodynamic target attainment of antibiotics in different patient populations

The adequacy of currently used dosing regimens of ciprofloxacin and ceftazidime are explored and if required improved.

Ongoing
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Isolation of 403 monoclonal antibodies from COVID-19 patients revealed convergent gene usage and multiple target epitopes

Ongoing
Resident immune cells in lesion formation in advanced MS
Resident immune cells in lesion formation in advanced MS

MS is characterized by inflammatory attacks of infiltrating leukocytes at onset but evolves into a progressive disease within the central nervous system.

Ongoing
Selective tumor antigen vaccine delivery to human CD169+ antigen presenting cells using ganglioside-liposomes
Selective tumor antigen vaccine delivery to human CD169+ antigen presenting cells using ganglioside-liposomes

Current immunotherapies only benefit a minority of cancer patients. We need new approaches to boost patients’ anti-tumor immune responses.

Ongoing
Single domain antibody targeting of the CD1d monomorphic antigen-presenting molecule induces potent anti-tumour activity
Single domain antibody targeting of the CD1d monomorphic antigen-presenting molecule induces potent anti-tumour activity

Camelid-derived single domain antibodies (VHH)5 specific for the human MHC class I-like molecule CD1d can modulate the function of CD1d-restricted T cell populations.

Ongoing
Study of a newfound immunometabolite in macrophages
Study of a newfound immunometabolite in macrophages

The lab of Jan Van den Bossche investigates how metabolism controls macrophages and disease progression.

Ongoing
TREAT NL (TREatment of ATopic eczema, The Netherlands) registry
TREAT NL (TREatment of ATopic eczema, The Netherlands) registry

The TREAT NL registry is a national registry of children and adults with moderate-to-severe atopic eczema (AE).

Ongoing
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