Suzanne A. B. M. Aarts
Focus of research
1. Cell-type specific actions of CD40-CD40L signaling in obesity: we generated CD40Lfl/fl and CD40fl/fl mice which are backcrossed with an array of cell-type specific Cre mice, which will give us additional information on the exact role and communication of the different CD40(L) expressing cell-types.
2. Identification of CD40-CD40L signal transduction pathways in multiple sclerosis: CD40-/- mice received a CD40 transgene with mutations in the respective TRAF-binding sites and are subjected to EAE.