Cancer Immunology
The immune system; the force witin that can cure cancer
Immunotherapy has been a breakthrough in the treatment of patients with melanoma, lung cancer and aggressive lymphoid malignancies. Nonetheless, many cancer types remain difficult to treat because of intense crosstalk between the tumor and the immune system, which leads to immune suppression that hampers an effective anti-tumor response.
Mission and goals
The Cancer Immunology program aims to improve the understanding of immunity against cancer, by immune monitoring of patients and investigating the immune suppressive mechanisms underlying tumor immune escape. The program also aims to find novel biomarkers to identify patients who may benefit from immunotherapy as well as discover and develop innovative therapeutic strategies that overcome immune escape. Altogether, the research performed within the Cancer Immunology program will advance the understanding and the clinical benefit of cancer immunotherapy.
The theme Cancer Immunology encompasses a broad representation of the field. Both solid tumors and hematopoietic cancers are investigated by multidisciplinary teams with strong (inter)national collaborations. To ensure scientific and societal impact fundamental research is translated into clinical applications. Vice versa, clinical findings are further investigated in the lab to unravel underlying mechanisms, with the aid of state of the art core facilities.
Research lines
Research lines of the Cancer Immunology theme comprise:
- Immunotherapy (e.d. engineered bispecific T cell engagers (BiTEs), CAR-T cells, dendritic cell-targeted vaccination, local immune modulation and engineered antibodies)
- Immune monitoring, biomarkers
- Cancer and autoimmunity
- Immune metabolism
- Tumor microenvironment
- Immune suppression
Program leaders
Program members
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A. Hakkert
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Aafke Creemers
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Adriaan D. Bins MD PhD, (Principal Investigator)
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Aldo Jongejan PhD
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Aleksandar B. Kirov
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Alfons van den Eertwegh PROF.DR., (Principal Investigator)
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Allison J. Klok
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Ammarina Chuwonpad
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Ana C. Pacheco Correia MSc
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Angela C. M. Luyf
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Angela L. Bosma
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Anna Elisabeth E. Jadczak
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Anna Kroeze
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Anne Steins
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Anne Uyterlinde DR.
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Anne W. J. Martens
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Annemarie Becker - Commissaris DR.
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Annemarie van de Geer MD PhD
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Annemieke Kuil BEng
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Arjan Griffioen PROF.DR., (Principal Investigator)
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Arjan van de Loosdrecht PROF.DR., (Principal Investigator)
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Arlene L. Oei PhD
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Armando A. C. van Bruggen MSc
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Arne A. Meesters
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Arnon P. Kater Prof. MD PhD, (Principal Investigator)
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Bahar Arik-Yetkin BSc
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Barbera D. C. van Schaik
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Bart Westerman DR.
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Bauke Ylstra PROF.DR., (Principal Investigator)
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Bernadien M. Nijmeijer MSc
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C.R. Leemans PROF.DR., (Principal Investigator)
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Cansu Tekin
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Carlijn Voermans , (Principal Investigator)
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Charles Hayfron-Benjamin
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Chiara Montironi
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Chris Meijer PROF.DR.
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Christina Henrike H. Steudel
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Christine van Gogh
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Christoffel A. Spek PhD, (Principal Investigator)
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Colin Heus
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Cornelia Uyl-de Groot PROF.
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Cornelis Haasbeek DR.
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Daan R. Loke
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Danial Lashgari
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Daniela Oprea - Lager MD, PhD, (Principal Investigator)
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Daniëlle Vugts DR., (Principal Investigator)
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Danny A. Zwijnenburg BEng
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Daoud Sie DR.
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Daphne de Jong PROF.DR., (Principal Investigator)
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David Noske DR., (Principal Investigator)
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Denise van Nieuwenhuize
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Dilara D. Savci Heijink MD
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E. M. Westerhout PhD
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Egbert Smit PROF.DR., (Principal Investigator)
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Elena Merino Tejero
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Eline C. Soer
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Eline Overwater
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Eline Zwart DRS.
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Elise M. A. Slob MSc
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Emma K. van de Weerdt
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Eric F. Eldering Prof. PhD, (Principal Investigator)
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Eric Meuleman PROF.DR.
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Erik Hooijberg DR., (Principal Investigator)
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Erik Thunnissen DR.
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Ester M. M. van Leeuwen PhD
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Esther Hulleman DR., (Principal Investigator)
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Esther J. M. Schilder-Tol
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Esther M. Zijlstra-Willems BEng
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Eva S. van Walree MD
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Evelien Roekevisch
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Famke Schneiders DR.
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Felix M. Behr MSc
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Floor Abbink DRS.
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Francesca Favaro
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Fred van Leeuwen Prof., (Principal Investigator)
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Frederike Dijk PhD
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Freyja H. M. van Lint
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Gabrielle Krebbers BEng
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Geert Kazemier PROF.DR., (Principal Investigator)
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Gemma Kenter PROF.DR., (Principal Investigator)
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George Scheffer
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Gerardus Visser
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Gerrit K. J. Hooijer MSc
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Gerrit Schuurhuis DR.
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Gert Ossenkoppele PROF.DR., (Principal Investigator)
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Gestur Vidarsson
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Greta de Jong MD
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Guus Fons MD PhD
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Hanne Meijers-Heijboer PROF.DR., (Principal Investigator)
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Hans B. G. Halfwerk BEng
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Hans Daniels DR.
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Hans M. Rodermond BEng
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Heinz-Josef Klumpen MD PhD, (Principal Investigator)
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Hella L. Aberson BEng
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Henk Verheul PROF.DR., (Principal Investigator)
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Henricus te Riele PROF.DR.
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Hergen Spits Prof. PhD, (Principal Investigator)
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Hildo C. E. R. E. J. Lantermans
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Idris Bahce DR.
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Inge Konings DR.
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Inger Nijhof DR.
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Ingrid A. M. Derks BEng
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Irene L. M. Klaassen
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Iris Nederlof
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Iske F. van Luijk MD
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Jaap Middeldorp PROF.DR., (Principal Investigator)
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Jacqueline Cloos PROF.DR., (Principal Investigator)
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Jan Buter DR.
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Jan J. B. Koster PhD
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Jan Willem W. Duitman PhD
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Janine S. Hahnlein
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Janna J. Laan
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Janneke F. Linnekamp MD
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Janny E. Lommerts MD
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Javier Romero Ros PhD
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Jelle E. Bousema
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Jeroen Belien DR.
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Joan H. de Jong BEng
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Job J. M. H. van Bragt MSc
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Johannes Castelijns PROF.DR., (Principal Investigator)
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Johannes van der Vliet PROF.DR., (Principal Investigator)
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Joke den Haan DR., (Principal Investigator)
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Josephine M. I. Vos
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Jouke Annema Prof. PhD, (Principal Investigator)
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Joyce Y. Buikhuisen
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Juan Garcia Vallejo DR., (Principal Investigator)
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Juan Ilarregui DR.
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Judith Meijer
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Julia Eder
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Juliette O. A. M. van Baal
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Karin C. Nuijens MD
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Katherine Cameron
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Katya Duvivier
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Klaas P. J. M. van Gisbergen PhD, (Principal Investigator)
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L. J. Gruneberg BEng
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Laura J. Schwarzmuller
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Laurence M. M. Crombag
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Le Zhang
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Leanne C. Helgers
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Lena Vaclavu MSc
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Leonie Hartl
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Levi B. Richards MSc
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Linda J. Valentijn PhD
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Lisa G. M. van Baarsen PhD, (Principal Investigator)
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Lizzy Wijmans
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Lotte Kleinendorst
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Louise W. Treffers
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M. Hamdi PhD
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Maaike C. Commandeur MSc
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Mahmoud I. A. Ibrahim MSc
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Marcel Verheij PROF.DR., (Principal Investigator)
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Marcel W. Bekkenk MD PhD
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Marcella Willemsen MSc
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Marchien G. Dallinga
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Marco V. Haselager
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Maria Bleeker DR.
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Maria L. Parga Vidal
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Marianne A. van de Pol PhD
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Marie José J. Kersten Prof. MD PhD, (Principal Investigator)
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Marieke L. Nijland
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Marielle Wondergem DR.
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Mariette Labots DR.
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Marije Lammers MSc
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Marinus H. J. van Oers Prof. PhD
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Marjolein van Egmond PROF.DR., (Principal Investigator)
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Marlijn van der Poel
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Marloes IJff MSc
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Marthe Minderman
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Maudy Walraven DRS.
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Maurik M. van den Heuvel
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Melissa Stunnenberg
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Mette Hazenberg Prof. MD PhD, (Principal Investigator)
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Mick Bennis
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Mohammed Khurshed
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Monika C. Wolkers PhD, (Principal Investigator)
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Monique E. C. M. Ursem-Oud
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Nathalie Swier MSc
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Niels van de Donk PROF.DR., (Principal Investigator)
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Niels W. P. Rutjes MD
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Nina E. de Groot
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Noortje Swart PROF.DR., (Principal Investigator)
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null Molenaar
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Paris J. Asif
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Parvin Tajik MD PhD
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Patricia M. Gomez Barila
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Paul Elbers DR.
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Peter de Boer
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Peter I. Bonta MD PhD
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Peter Sminia DR., (Principal Investigator)
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Pierre Agnass MEng
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Pieter Wesseling PROF.DR., (Principal Investigator)
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Pim de Graaf DR., (Principal Investigator)
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Prashanthi Ramesh
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Ramin Sarrami
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Raphaële van Litsenburg DR.
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Reina Mebius PROF.DR., (Principal Investigator)
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René Leen
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Renee R. C. E. Schreurs MSc
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Renske Steenbergen PROF.DR., (Principal Investigator)
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Richard Groen DR.