Proof of Concept Grants

As an organization Amsterdam Neuroscience has organized its research in a focused way along the nine translational research programs, each around specific brain and nervous system diseases, disease mechanisms, or technology innovations. We will continue to keep this focus but also want to stimulate young and promising researchers.

To stimulate young and promosing research, in the period 2016-2019, 46 outstanding proof of concept (PoCs) and collaborative projects were funded by Amsterdam Neuroscience, for a total of 6.5 million euros. For the period 2020-2022, we kickstarted a new round of such projects, with a total of 3 million euros of funding. Here is the index of the internally awarded research alliance and PoC projects for the period 2020-2022.

Brain Imaging

Applicants Institute Research Project
Moji Aghajani, Laura Nawijn Amsterdam UMC, location VUmc Enigma related project: application of machine learning to neuroimaging data
Matthan Caan Amsterdam UMC, location AMC Quantitative AI framework to quantify tissue parameters in volunteers and high resolution lesion volume in MS
Sandeep Golla, Ronald Boellaard Amsterdam UMC, location VUmc PET image-based classification of amyloid and/or tau positivity in minimal cognitive impairment and Alzheimer’s disease (AD) and classification of abnormalities in dopamine transporter (DAT) SPECT in parkinsonian patients
Petra Pouwels Amsterdam UMC, location VUmc Convolutional neural networks (CNN) on the quantification of MRS
Hisse Arnts, Fleur van Rootselaar Amsterdam UMC, location AMC Machine learning (ML) paradigms to optimize EEG recording and data interpretation

Systems & Network Neuroscience

Applicants Institute Research Project
Umberto Olcese University of Amsterdam Excitation - inhibition ratio as a translational concept: optogenetic validation of a novel method to stratify autism spectrum disorder
Erwin van Vliet University of Amsterdam Putting a restless locus coeruleus to sleep to resolve distress of emotional memories
Aishwarya Parthasarathy, Ingo Willuhn Amsterdam UMC, location AMC A novel dimensional-reduction method for optical and electrophysiological data to identify neuron population codes predictive of behavior
Ilse van Straaten Amsterdam UMC, location VUmc Physiological and genetic fingerprints of seizure freedom after epilepsy surgery
Menno Schoonheim Amsterdam UMC, location VUmc Modelling the network collapse in MS
Natalia Goriounova Vrije Universiteit Amsterdam From single neurons to brain networks of cogntion

Cellular & Molecular Mechanisms

Applicants Institute Research Project
Priyanka Rao-Ruiz, Jan van Weering Vrije Universiteit Amsterdam GRASPING the diverse molecular architecture of hippocampal synaptomes
Niels Cornelisse, Marieke Meijer, Klaus Linkenkaer-Hansen Vrije Universiteit Amsterdam Connecting E/I disbalance at the single cell and brain level in a mouse model for intellectual disability
Mark Verheijen, Rogier Min, Vivi Heine VU Amsterdam, Amsterdam UMC Visualizing extracellular and intracellular glutamate dynamics in neuron‐astrocyte networks
Aniko Korosi University of Amsterdam The impact of early-life stress on hypothalamic microglial immunometabolism

Complex Trait Genetics

Applicants Institute Research Project
Siemon de Lange, Lianne Scholtens Vrije Universiteit Amsterdam Genotyping cortical architecture as a stepping stone to unraveling biological disease pathways
Eva van Walree Vrije Universiteit Amsterdam The effect of parental relatedness on complex diseases
Jeanne Savage Vrije Universiteit Amsterdam Understanding the origins of alcohol misuse through genetically stratified subgroups
Yuri Milaneshi, Jorien Treur, Adinda Janse Amsterdam UMC, Location VUmc Using genomics to examine the causal role of immuno-metabolic alterations in depressive symptoms
Suzanne Miedema, Lianne Reus Vrije Universiteit Amsterdam A multi-omics approach to modeling disease mechanisms in sporadic frontotemporal dementia


Applicants Institute Research Project
Rosa Crespo Rodrguez Amsterdam UMC, location VUmc Molecular fingerprint of tau pathology - a personalized medicine approach
Lars van der Heiden University of Amsterdam Towards a cure for Parkinson’s disease: Identification of Mcl1 interacting proteins that prevent death of dopamine neurons
Ysbrand van der Werf Amsterdam UMC, location VUmc Deep phenoytyping of REM sleep behaviour disorder in patients with Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB)
Joke Dijk Amsterdam UMC, location AMC Brain involvement in neuropathic tremor
Ronald van Kesteren Vrije Universiteit Amsterdam Differential localization, composition and function of extracellular vesicles in AD
Sven van der Lee Amsterdam UMC, location VUmc Amsterdam-wide genetics cohort of neurodegenerative diseases

Neuroinfection & -inflammation

Applicants Institute Research Project
Matthijs Brouwer Amsterdam UMC, location AMC The program leader and taskforce members of neuroinfection and inflammation have chosen to invest the research funding in complex biobanking for the upcoming 3 years. This will involve all diseases within the scope of neuroinfection and inflammation, and currently applications to participate have been received from researchers on multiple sclerosis, encephalitis, bacterial meningitis, inflammatory neuropathies (mostly chronic inflammatory demyelinating polyneuropathy - CIDP), neurosarcoidosis and myositis

Neurovascular disorders

Applicants Institute Research Project
Gijs Kooij, Inge Burger-Mulder, Umberto Olcese, Elga de Vries, Ed van Bavel, Jonathan Coutinho Amsterdam UMC, University of Amsterdam Novel markers and therapeutic opportunities for ischemic stroke and subarachnoid hemorrhage
Peter Vandertop, Nicole Juffermans, Dagmar Verbaan, Bert Coert, Maud Tjerkstra Amsterdam UMC, location AMC The ability of ROTEM to detect hypercoagulability and to predict onset of cerebral ischemia in patients with subarachnoid haemorrhage
Anne-Eva van der Wijk, Erik Bakker, Ed van Bavel Amsterdam UMC, location AMC Microsphere extravasation for drug delivery in the brain

Compulsivity, Impulsivity & Attention

Applicants Institute Research Project
Jeannette Lorteije University of Amsterdam Of Mice and Men, a cross-species measure of impulsivity
Karin Verweij Amsterdam UMC, location AMC Cadm2 in addiction and risk-taking behaviour
Chris Vriend Amsterdam UMC, location VUmc The thalamus, a gateway to obsessive-compulsive disorder
Klaus Linkenkaer-Hansen, Hilgo Bruining, Fleur van Rootselaar Vrije Universiteit Amsterdam Deep neural networks for automated EEG cleaning

Mood, Anxiety, Psychosis, Stress & Sleep

Applicants Institute Research Project
Leonidas Faliagkas, Priyanka Rao-Ruiz Vrije Universiteit Amsterdam Optogenetic stimulation of Locus Coeruleus (LC) neurons to model restless sleep
Joram Mul, Sabine Spijker University of Amsterdam Working Out the Antidepressant Effects of Exercise
Laura Nawijn Amsterdam UMC, location VUmc Effects of stress on brain ageing
Hein van Marle Amsterdam UMC, location VUmc A neuroimaging investigation into the role of sleep in the treatment of PTSD