Research highlights

Major breakthroughs in lymphoma and leukemia therapy: Ibrutinib and Venetoclax Important contributions are made to preclinical and clinical investigations involving targeted therapies for lymphoma and leukemia patients: from bench to bedside, and back!

Completed

Radiomics and machine learning for response prediction in Diffuse Large B-Cell Lymphoma patients using advanced medical imaging technologies Radiomics technology extracts a large number of features from medical imaging to predict treatment response.

Ongoing

Gluten-related Neurological Disorders Various neurodegenerative disorders have been associated with an inappropriate reaction to dietary gluten intake. The underlying neuropathological mechanism is still unclear.

Ongoing

Perturbation-based gait training programme to prevent falls of older adults Developing a treadmill based fall-preventive training programme to investigate the effects on functional balance and gait performance, self-efficacy and physical activity in daily life.

Ongoing

(Cost-)effectiveness of the transmural trauma care model Assessing the (cost-)effectiveness of the improved version of the TTCM as compared to usual care in a multicenter trial with controlled before-and-after design.

Ongoing

Development of machine learning prediction models on long term cognitive and motor outcome of preterm born children Long term outcome prediction in preterm children is impossible or inaccurate. To improve this we develop a prediction model with machine learning techniques.

Ongoing

Targeting hepatic bile salt uptake to treat cholestasis or the metabolic syndrome In this project we aim to understand the role of bile acids (and its dynamics) in energy, fat and glucose homeostasis, and in inflammation.

Ongoing

Daily electrical stimulation to prevent recurring pressure ulcers in patients with a spinal cord injury This project compares usual care with daily electrical stimulation to prevent recurrent PUs (Pressure Ulcers) in people with spinal cord injuries.

Ongoing

Clinical and translational research in patients with polyposis syndromes One of our main goals in clinical research in patients with polyposis syndromes is the optimization and personalization of endoscopic surveillance.

Ongoing

Our research highlights