Kwinten Sliepen

PhD

AII - Infectious Diseases Affiliatie UvA Other Academic Staff, Medical Microbiology and Infection Prevention Research Associate, Medical Microbiology and Infection Prevention

Specialization

hepatitis C virus (HCV), HIV-1, envelope glycoproteins, vaccines, nanoparticles

Focus of research

Designing hepatitis C virus (HCV) E1E2 glycoproteins for structural studies and vaccine studies.

Producing and designing novel HIV-1 envelope glycoproteins.

Latest publications

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike
Derking, R., Allen, J. D., Cottrell, C. A., Sliepen, K., Seabright, G. E., Lee, W.-H., Aldon, Y., Rantalainen, K., Antanasijevic, A., Copps, J., Yasmeen, A., Cupo, A., Cruz Portillo, V. M., Poniman, M., Bol, N., van der Woude, P., de Taeye, S. W., van den Kerkhof, T. L. G. M., Klasse, P. J. & Ozorowski, G. & 5 others, van Gils, M. J., Moore, J. P., Ward, A. B., Crispin, M. & Sanders, R. W., 6 Apr 2021, In: Cell reports. 35, 1, 108933.
Research output: Contribution to journal › Article* › Academic › peer-review
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
Brouwer, P. J. M., Brinkkemper, M., Maisonnasse, P., Dereuddre-Bosquet, N., Grobben, M., Claireaux, M., de Gast, M., Marlin, R., Chesnais, V., Diry, S. G., Allen, J. D., Watanabe, Y., Giezen, J. M., Kerster, G., Turner, H. L., van der Straten, K., van der Linden, C. A., Aldon, Y., Naninck, T. & Bontjer, I. & 27 others, Burger, J. A., Poniman, M., Mykytyn, A. Z., Okba, N. M. A., Schermer, E. E., van Breemen, M. J., Ravichandran, R., Caniels, T. G., van Schooten, J., Kahlaoui, N., Contreras, V., Lemaître, J., Chapon, C., Fang, R. H. T., Villaudy, J., Sliepen, K., van der Velden, Y. U., Haagmans, B. L., de Bree, G. J., Ginoux, E., Ward, A. B., Crispin, M., King, N. P., van der Werf, S., van Gils, M. J., le Grand, R. & Sanders, R. W., 4 Mar 2021, In: Cell. 184, 5, p. 1188-1200.e19 36 p., 365726.
Research output: Contribution to journal › Article* › Academic › peer-review
Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins
Kalemera, M. D., Capella-Pujol, J., Chumbe, A., Underwood, A., Bull, R. A., Schinkel, J., Sliepen, K. & Grove, J., 2021, In: Journal of general virology. 102, 1, 001512.
Research output: Contribution to journal › Article* › Academic › peer-review
All publications

Kwinten Sliepen

Specialization

Focus of research

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins

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