AGEM Tager lecture: Felix Hartmann

Theme Metabolism

Target audience Researchers

Language English

General

Each year, the AGEM research institute organizes a seminar series focused on metabolism: the Tager Lectures. These lectures are named after Professor Joseph Tager, who made important contributions to Fabry, Pompe and Gaucher disease and had a major impact on our understanding of peroxisomal diseases. He was chairman of the Biochemistry Department at the University of Amsterdam (1980-1991).

On Thursday November 9, the Tager seminar series will continue with a new lecture by Dr. Felix Hartmann of the German Cancer Research Center (DKFZ) in Heidelberg, Germany.

Quantifying metabolic regulation in tissue microenvironments via multiplexed imaging

The progression and clinical outcome of human cancer are influenced by cellular interactions in the tissue microenvironment. The laboratory Dr. Hartmann works at, strives to understand how such interactions influence the behavior of the human immune system. Specifically, they are studying how metabolic interactions between T cells, macrophages, and tumor cells determine immune function and tumor progression.

To address these questions, they employ a novel proteomic imaging technology termed multiplexed ion beam imaging (MIBI). MIBI enables simultaneous quantification of more than 40 proteins and their spatial localization directly in human tissues.

Picture explaining the research by Dr. Felix Hartmann

During the lecture, Dr. Hartmann will demonstrate the use of this technology to analyze the metabolic regulation of human immune cells in clinical tissues and will give insight into functional studies on the relevance of metabolic pathways using genetic manipulation and human organoid cultures. Overall, the goal is to advance the understanding of the interactions between the immune system and the local tissue structure and thus contribute to future improvements in the immunotherapy of human cancer.