Project title: Regulation of tip cell formation and sprouting angiogenesis
Location: VUmc, Angiogenesis Laboratory, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands.
General
The research of the Angiogenesis Laboratory at the Department of Medical Oncology of the VU University Medical Center in Amsterdam aims to unravel fundamental processes and mechanisms of angiogenesis and vascular development using molecular and cell biological techniques. The acquired knowledge is used to develop new treatment modalities and diagnostic tools for clinical applications. We work with an enthousiastic and motivated multidisplinary team of about 10 researchers.
Project description
The formation of new blood vessels by sprouting angiogenesis is essential for a variety of pathophysiological processes including embryonic development, wound healing, and tumor growth. Sprouting angiogenesis depends on formation of specialized ‘leader’ cells called tip cells, which branch off from primary vessels and migrate into the environment to form new vessels. In this project, we will investigate mechanisms underlying tip cell formation and sprouting.
Job requirements
We are looking for an enthusiastic MSc student with interest in vascular biology, cell biology, and microscopy. In this project we will be using a variety of cell-biological and biochemical methods including endothelial cell culture, sprouting assays, flow cytometry, confocal microscopy, live imaging, Q-PCR, and Western blotting.
Information
Dr. C. Margadant, Angiogenesis Laboratory, Department of Medical Oncology, VUmc, Amsterdam, the Netherlands. E-mail: c.margadant@amsterdamumc.nl.