Grants given to young academics have a multi layered effect; they can bring innovative research results in the exact direction the institute is aiming for; they often bring new, multidisciplinary research collaboration, and can give young aspiring academics the push they want in their career.
Below are some testimonials from AMS laureates, which show what the AMS grants have brought them.
Early career grant 2018
In 2018, I received a personal grant from Amsterdam Movement Sciences to develop Imaging technologies to map post-traumatic muscle fibrosis and its functional impact. This grant is an interdisciplinary cooperation between the departments of Biomedical Engineering & Physics, Department of Radiology & Nuclear Medicine and the Faculty of Human Movement Sciences. Currently, we are still working on the implementation of these innovative techniques.
Receiving this AMS grant had a personal and scientific impact. For me, this grant was an essential step into my path towards becoming an independent researcher. In particular, it really strengthened my CV, making me much more competitive for future grant and fellowship applications. Ultimately it led to receiving the personal Veni grant in the round of 2020, which allows me to continue my path of becoming an independent researcher.
On a more scientific note this grant also initiated a new collaboration with the department of Human Movement Sciences at VU University, focused on comparing two advanced imaging modalities for measuring muscle architectural features. In addition, the research findings are currently serving as input for a larger grant application. Hopefully, it will lead to even more interdisciplinary collaborations and grant applications in the future.
Marjolein van der Krogt
In 2018, the AMS Innovation Call for Tenure Development financed the project PREdictive SimulaTion of Impaired Gait Evaluations (PRESTIGE), aiming to develop and validate simulations that predict the effect of impairments on gait.
With the funding, a part-time post-doc was hired (Niels Waterval), a joint PhD trajectory in collaboration with Griffith University in Australia was set up (Kirsten Veerkamp), and dedicated research time for the PI (Marjolein van der Krogt) was made possible. In collaboration with the TU Delft (Thomas Geijtenbeek), we studied the effect of weakness, contractures and spasticity on gait.
The first two publications are now submitted, evaluating the effect of different cost functions for predictive simulations, and predicting the effect of calf muscle weakness on gait, compared with experimental patient data. Work on simulating the effects of contractures and spasticity, and comparing this with experimental patient data, is ongoing.
Furthermore, Niels Waterval acquired additional funding from the Innovative Medical Device Initiative (IMDI) ‘Break Through Projects’ (1,5 y full-time postdoc), to develop precision simulations and predict the effect of individual optimal ankle foot orthoses for patients with calf muscle weakness. Ultimately, we aim to further develop this simulation framework, in order to predict the effect of different treatments on gait for our patient populations.
Tenure development grant 2018
Jaap van Netten
Thanks to the AMS grant for our research project DIALOAD, and with additional funding obtained elsewhere, we are now in the middle of two prospective studies.
With these studies, we aim to unravel biomechanical and behavioural mechanisms of the development of foot ulcers in people with diabetes (study 1), and the healing of these ulcers once developed (study 2). These studies contribute to the development of a new and comprehensive load-capacity model for people with diabetic foot disease.
Stimulated by this grant, we have been able to increase our inter-disciplinary and inter-departmental collaborations within AMS, but also collaborations with other Dutch hospitals and research groups in Australia and the US. This has already led to additional grants, collaborative research output, and clinical implementations, with the main studies still ongoing. For me personally, the grant has provided room to grow into a more senior research position, recognizable within AMS and worldwide.
Tenure development grant 2017
Osteogenesis Imperfecta (OI) is a genetic disease of osteoporosis and skeletal dysplasia, resulting in numerous bone fractures during the patients’ lifetime. The molecular cause is defects in collagen type I. Despite being classified as a rare disease, OI is the most common genetic disease of decreased bone mineral density; in the Netherlands only, at least 1,000 patients exist.
The AMS innovation grant gave us the opportunity to address the diagnosis and treatment of OI. By screening OI patients with no mutations in the known causative OI genes, we identified the gene KDELR2 as a new genetic cause for OI revealing a new pathological mechanism for the disease (AJHG, 2020). This gene is now being used in the molecular diagnosis of OI patients.
AMS also enabled us to proceed with the preclinical validation of collagen-upregulating compounds as therapy for osteoporosis. These compounds have been shown in an in vitro model, to stimulate collagen production in osteoblasts derived from OI patients with collagen deficiency. Their current analysis in osteoporosis models will address their effectiveness in the treatment of OI and other forms of osteoporosis to hopefully justify their transition to clinical trials.
With the support of AMS we have improved the diagnosis of OI patients
The grant also contributed to my accreditation as Amsterdam UMC Principal Investigator.
|Elke Vlemincx||Investment grant||Portable Respiratory Monitor|
|Marike van der Leeden||Investment grant||Activity Monitors|
|Evert Verhagen||Program investment grant||Program strengthening|
|Raymond Ostelo||Program investment grant||Program strengthening|
|Nathalie Bravenboer||Program investment grant||Program strengthening|
|Mirjam Pijnappels||Program investment grant||Program strengthening|
|Sicco Bus||Program investment grant||Program strengthening|
|Tristan Buck||PhD talent grant||Treatment of Cartilage lesions in the ankle|
|Lauria Claeys||PhD talent grant||Ultra-high strength polylactide|
|Moritz Eggelbusch||PhD talent grant||Mitochondrial supercomplex function|
|Meghan Koop||PhD talent grant||INHALE-study|
|Jorien Langstraat||PhD talent grant||Genetic Analysis of Café-au-Lait skin cells|
|Moira van Leeuwen||PhD talent grant||Foot placement control can be trained|
|Sander Oorschot||PhD talent grant||Optimizing protocol selection for cardiopulmonary exercise testing|
|Quinten Rikken||PhD talent grant||Ultra-Long-Term Clinical Success of Treatment for Cartilage Lesions in the Ankle|
|Wouter Schalllig||PhD talent grant||Multi-segment foot kinetics|
|Ivo Lutke Schiphold||PhD talent grant||Different trajectories for people with acute neck pain|
|Andi Shi||PhD talent grant||Whole transcriptome sequencing analysis within skeletal muscle in absence of Acvr1b and/or Tgfbr1|
|Lisa Worner||PhD talent grant||Valgus stress overload|
|Sanne Ettema||MA-student grant||Effect of prolonged moderate-intensity walking|
|Esther Goudzwaard||MA-student grant||HIIT-the track|
|Max Keller||MA-student grant||Influence of prolonged walking|
|Isa Mast||MA-student grant||Dynamic Arterial Spin Labeling MRI|
|Marike van der Leeden||PhD grant||Development and evaluation of an accelerometer based feedback and coaching intervention for patients at risk for functional decline admitted to the hospital|
|Robert Wust||PhD grant||Metabolic dysfunction and anabolic resistance during inactivity and systemic inflammation|
|Nathalie Bravenboer||Investment grant||Mechanical loading device / Instron electropulse E1000|
|Jaap van Netten||Tenure development / mid-career||Biomechanical, activity and adherence profiles of people with diabetes in a comprehensive load-capacity model of foot ulceration|
|Marjolein van der Krogt||Tenure development / mid-career||Comprehensive neuromusculoskeletal modelling to predict the effect of impairments on gait in children with cerebral palsy|
|Harald Jørstad||Tenure developmetn / clinical leadership||Elite sports: addressing the heart of the matter|
|Helga Haberfehlner||Post-Doc / Early Career Call||Objective assessment of dystonia and choreoathetosis in children and adolescent with dyskinetic cerebral palsy based on machine learning|
|Melissa Hooijmans||Post-Doc / Early Career Call||Imaging of post-traumatic muscle fibrosis and its functional impact (fibrofit)|
|Roland Rossler||Post-Doc / Early Career Call||Finding the right balance: determining safe and healthy physical activity load|
|Ruud Wellenberg||Post-Doc / Early Career Call||Quantitative weight-bearing CT for musculoskeletal disorders.|
|Alessandro Chiarotto||Grant Application||Developing a new method to assess the perceived importance of the effects of health interventions for patients with musculoskeletal and rheumatic conditions|
|Erwin van Wegen||Grant Application||Do-iT Parkinson; Effects of Dose and type of exercise Training on exercise-induced neuroplasticity in human Parkinson’s disease|
|Onno Baur||Feasability studies||Making dynamic imaging of the ankle possible|
|Heleen Beckerman||Feasability studies||Cardiorespiratory fitness in newly diagnosed patients with Relapsing Remitting Multiple Sclerosis compared to matched healthy controls: already lagging behind from the start?|
|Renate de Jongh||Feasability studies||A feasibility and pilot study of non-invasive diagnostic techniques in renal osteodystrophy: 18F-fluoride positron emission tomography and serum non-oxidized PTH|
|Eric Voorn||Feasability studies||The development of an easily applicable measurement tool for systematic prescription and evaluation of aerobic training in adults and children with slowly progressive neuromuscular diseases|
|Robin Blom||PhD talent grant||Three-dimensional Quantification of Operative Reduction for Posterior Malleolar Fragments in Rotational Type Ankle Fractures to Improve the Long-term Clinical Outcome|
|Jetske Viveen||PhD talent grant||The sensitivity to change of daily-life gait quality characteristics in older adults|
|Guido WEide||PhD talent grant||Knowledge transfer from a VUmc developed 3D-ultrasound approach to measure invivo morphometry of skeletal muscle at the AMC|
|Sabine Schootemeijer||MA student grant||The sensitivity to change of daily-life gait quality characteristics in older adults.|
|Mareille Post||MA student grant||Safety and effectiveness evaluation of pre-bended rods in patients with adolescent idiopathic scoliosis|
|Babette Zwaard||MA student grant||The evaluation of gait and dynamic balance performance before and after Gamma Knife Thalamotomy in patients with severe Essential Tremor|
|Richard Jaspers||Investment grant||S‐Chiaro‐ST Optics11 including Dynamic module and support|
|Dimitra Micha||Tenure development||Old drugs with new indications ease the path to the clinic for rare bone disorders|
|Marike van der Schaaf||Tenure development||Exercise physiology in critically ill patients|
|Alessandro Chiarotto||Post-doc career||Optimizing physical functioning measurement in low back pain|
|Kaj Emanuel||Post-doc career||The effect of knee osteoarthritis on passive natural knee kinematics|
|Guus Reurink||Post-doc career||Innovative tools and interventions to prevent muscle injuries, optimise treatment of injured athletes and increase (elite) sports performance|
|Nathalie Bravenboer||Grant application||A novel cell culture platform|
|Sicco Bus||Grant application||The prevention of foot ulceration and amputation in diabetes|
|Merel Brehm||Infrastructure||C-Mill (MotekForcelink) instrumented treadmill|
|Harald Jørstad||Infrastructure||MRI-compatible ergometer (Cardiac MRI during physiological exercise: a new gold standard for stress imaging)|
|Carel Meskers||Infrastructure||PROFITS- DPM : PRecision prOFiling to Improve long-term ouTcome after Stroke: Dynamic Prognosis Module / GEMSTRACKER platform|
|Evert Verhagen||Infrastructure||OptiForm Database|
|Vera Meekes||MA-student grant||The use of magnetic resonance imaging (MRI) to assess skeletal muscle characteristics|
|Kirsten Veerkamp||MA-student grant||Improving patient-specific musculoskeletal models in children with cerebral palsy|
|Marit Zandbergen||MA-student grant||The effect of different foot models on the simulated muscle-tendon lengths of the gastrocnemius medialis and lateralis in both children with spastic cerebral palsy and typically developing children|
|Marjolein van der Krogt||Investment grant||Upgrade to EMG system|
|Carel Meskers||Investment grant||Activity monitors & license|
|Erwin van Wegen||Investment grant||Sensory feedback for Grail VR system|