Fatigue is a highly prevalent problem in inflammatory disease patients. Not only in active disease, but also in patients in remission. The mechanisms that drive fatigue are not known. To be able to develop novel therapies we need to have a better understanding of the molecular pathways that lead to fatigue in chronic intestinal inflammation.

The group of Dr. Wildenberg studies the molecular pathways using a mouse model of fatigue. Their hypothesis is that during intestinal inflammation, a certain cell type in the gut is altered and that reversal of this problem is important for medication to be effective. It is also known that during short term infectious diseases the activation of similar cell types in the brain can result in fever, lack of appetite and general malaise. It is therefore likely that wrongful activation of these cells during chronic inflammation also plays a role in the development of fatigue. They study how these brain cells are influenced by chronic inflammatory diseases and how we can modulate these cells to reverse the resulting fatigue.

The group of Dr. te Velde studies the molecular mechanisms of fatigue related to chronic low grade inflammation. Several pathways are studied in vitro, ex vivo, in silico and in patients with IBD.

We are building a danger associated molecular pattern (DAMP) activation status panel in order to measure sensitivity for immune activation when pattern recognition receptors detecting DAMPs are predisposed.

Amsterdam UMC researchers involved in this project: