Neurovascular Disorders
Rationale and common goals
The focus of this program is on acute stroke.
- Neurovascular imaging and image-guided interventions and surgical repair of intracranial aneurysms in the Neurovascular Intervention Center Amsterdam (NICA).
- Acute therapies (intravenous thrombolysis and endovascular treatment) for ischemic stroke.
- Secondary prevention for ischemic stroke, carotid artery disease and cerebral venous thrombosis.
Assets
Combining stroke patients from both VUmc and AMC results in a unique cohort of over a thousand ischemic stroke patients per year. Very recently, two large clinical phase III trials developed by AMC PIs (Roos, Nederkoorn, Majoie) concerning acute treatment of ischemic stroke were finished and published in high-impact journals (MrClean NEJM 2014, PASS Lancet 2015). We are among the top 3 research groups on cerebral venous thrombosis worldwide and involved in the three largest ongoing international clinical studies on cerebral venous thrombosis (PIs Stam, Coutinho). The database of subarachnoid haemorrhage (SAH) patients contains almost six hundred prospectively and nine hundred retrospectively collected patients. The AMC is coordinating a nation-wide RCT in SAH (ULTRA; Vandertop, Verbaan). Within the VU University medical center, there is expertise on prognostic research and technology-driven rehabilitation trials (G. Kwakkel), as well as longitudinal research targeted on mechanisms that drive neurological recovery and use adaption strategies early post stroke. The Amsterdam Stroke Network will form the basis to set up new studies.
Translational links: Advanced imaging techniques
This research program has a strong clinical focus. Basic scientists mainly contribute in advanced imaging techniques (neuroradiology) and for translational studies we work with the vascular medicine and the vascular pathology department, and with Sanquin. Further collaboration with basic science partners in AMC and VU, to unravel causes of stroke, is one of our targets in the near future.
Making the difference
Neurovascular research in Amsterdam has a strong track record in:
- Designing and performing large clinical trials for the treatment of acute stroke.
- Diagnosis and secondary prevention of stroke.
- Unraveling causes of stroke.
Program leaders
Taskforce team
Program members
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Adrien E. D. Groot MD
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Agnetha E. Bruggeman MD
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Angela van Weert BSc
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Arya Lekshmi Asha Rajasekharan Nair
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Bart J. Emmer
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Bart M. W. Cornelissen MSc
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Bas van der Veen MD MSc
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Bernard A. Coert
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Carel Meskers DR., (Principal Investigator)
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Charles Majoie Prof. MD PhD, (Principal Investigator)
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Dagmar Verbaan PhD, (Principal Investigator)
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Daphne M. P. Naessens MSc
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Ed van Bavel Prof. PhD, (Principal Investigator)
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Elga de Vries PROF.DR., (Principal Investigator)
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Erik T. P. Bakker PhD
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Erwin van Wegen Drs. Human Movement Science, (Principal Investigator)
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Fianne H. M. Spaander
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Gerrit J. Bouma MD PhD
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Gert Kwakkel PROF.DR., (Principal Investigator)
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H Marquering PhD, (Principal Investigator)
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Haryadi Prasetya MEng
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Henk van Voorst MD MSc
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IJsbrand J. A. J. Zijlstra
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Inge A. Mulder
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Inge Mulder
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Ivo G. H. Jansen
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Janina C. V. Schwarz MSc
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Jantien Hoogmoed
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Jonathan Coutinho MD PhD, (Principal Investigator)
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Joseph Bot DR.
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Judith de Vos BSc
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Katinka R. van Kranendonk
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Kilian M. Treurniet
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Lucas A. Ramos
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Lucie A. van den Berg MD
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Ludo F. M. Beenen MD
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Luka C. Liebrand MSc
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Madieke I. Liem MD
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Manon Kappelhof MD
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Manon L. Tolhuisen MSc
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Marie Visser DR.
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Marieke E. S. Sprengers PhD
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Martine M. A. C. van Doorn MD
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Mat Daemen Prof. PhD, (Principal Investigator)
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Maud A. Tjerkstra BSc
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Mayte Sanchez van Kammen
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Melanie Hafdi MD MSc
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Merih I. Baharoglu MD
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Michiel B. Lequin
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Miou S. Koopman
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Naomi Buntsma MSc
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Natalie E. LeCouffe
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Nikki A. Lammers
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Paul J. Nederkoorn MD PhD, (Principal Investigator)
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Praneeta R. Konduri
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R.D. Fontijn
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Rene Post
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René van den Berg PhD
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Renske M. van den Berg
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Rozemarije A. Holewijn
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Sophie A. van den Berg MD
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Sophie E. C. M. van de Vijfeijken
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Steven Immenga
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Taco Goedemans
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Thomas P. Zonneveld
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Twan J. van Velzen MD MSc
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Valeria Guglielmi
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Wessel E. van der Steen MD
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Willeke F. Westendorp MD
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William Vandertop Prof. PhD, (Principal Investigator)
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Wing Hee Fung
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Yvo B. W. E. M. Roos Prof. PhD, (Principal Investigator)