Specialization
Transcriptional regulation of metabolism
Focus of research
* Contribution of the LXR-IDOL-LDLR axis to cholesterol metabolism
* Identification of novel metabolic genes
* Studying the contribution of the UPS system to metabolism
Amsterdam Cardiovascular Sciences
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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
Loregger, A., Raaben, M., Nieuwenhuis, J., Tan, J. M. E., Jae, L. T., van den Hengel, L. G., Hendrix, S., van den Berg, M., Scheij, S., Song, J.-Y., Huijbers, I. J., Kroese, L. J., Ottenhoff, R., van Weeghel, M., van de Sluis, B., Brummelkamp, T. & Zelcer, N., 1 Dec 2020, In: Nature communications. 11, 1, 1128.Research output: Contribution to journal › Article* › Academic › peer-review
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Regulation of intestinal LDLR by the LXR-IDOL axis
van Loon, N. M., van Wouw, S. A. E., Ottenhoff, R., Nelson, J. K., Kingma, J., Scheij, S., Moeton, M. & Zelcer, N., 1 Dec 2020, In: Atherosclerosis. 315, p. 1-9 9 p.Research output: Contribution to journal › Article* › Academic › peer-review
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Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site
Martinelli, L., Adamopoulos, A., Johansson, P., Wan, P. T., Gunnarsson, J., Guo, H., Boyd, H., Zelcer, N. & Sixma, T. K., 25 Sept 2020, In: Journal of biological chemistry. 295, 39, p. 13570-13583 14 p.Research output: Contribution to journal › Article* › Academic › peer-review
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