ACS provides funds to support talented ACS researchers and to stimulate collaboration between ACS researchers within Amsterdam UMC. Each year several calls are organized for ACS researchers at different stages of their careers.
Each year, ACS organizes grant rounds for the Postdoc grant, MD/PhD grant and the Out of the Box (OOTB) grant. The Postdoc and MD/PhD grants are for excellent young basic and clinical researchers, respectively, and aim to support talented ACS researchers. The Postdoc grant provides the opportunity to obtain postdoc experience for a period of one year in a prestigious research center abroad. The MD/PhD grant covers one day a week protected research time for a two-year post-doctoral project for medical specialists in training. The OOTB grant aims at supporting ACS project leaders to set up new collaborations within ACS. For more information on the different grants, see the overview of ACS grants.
Two laureates from 2016 tell what the ACS grant has brought them.
Marten Hoeksema - ACS Postdoc grant 2016
The ACS Postdoc fellowship allowed me to perform my post-doc in the lab of Professor Glass, a world expert in macrophages and gene regulation. As the result of the vibrant and collaborative environment at UC San Diego, I have been able to master novel state-of-the-art genetic techniques and analysis tools, and to expand my scientific network. During my time here, I have identified key transcription factors for activation of both anti-inflammatory and pro-inflammatory gene enhancers in macrophages, fundamental information that we can use for inflammatory and cardiovascular diseases. Based on these findings, I applied for additional research grants and was recently awarded with the American Heart Association Postdoc grant and a Marie Curie Individual Fellowship.
Marten Hoeksema: I highly recommend young researchers apply for the ACS postdoc grant to visit a lab abroad. It has been a great life experience for me, as I have learned so much both inside and outside the lab!
Ronak Delewi – ACS MD/PhD grant 2016
During my residency in Cardiology at the AMC, I remained captivated by cardiovascular research in the hope of improving clinical outcomes on a larger scale. Although I am a devoted physician, I missed having dedicated research time. As such, this ACS MD/PhD grant provided the perfect combination for my last years of training. I spent this time performing research in the field of transcatheter aortic valve implantation, supervising PhD students and also set up new research ideas and grants. It truly was the foundation for the future, where I will hopefully be able to further combine the love for research and interventional cardiology.
Name
Grant
Project
Marion van Vugt
Postdoc
Genetically guided drug target identification in hypertrophic cardiomyopathy
Barbara Verhaar
Postdoc
Uncovering the salt-resistant microbiome: insights into intestinal sodium absorption and hpertension
Stijn Meijnikman
MD/PhD
Inhibiting endogenous ethanol to decrease the burden of intestinal cellular senescence
Frits Mulder
MD/PhD
Towards prevention of arterial thrombosis in cancer: identifying critical risk factors
Marc Hilhorst and Annette Neele
Out of the Box
Monocyte activation by proteinuria in patients with chronic kidney disease
Nimrat Grewal and Arjan Houweling
Out of the Box
Genetic and Epigenomic Insights into Thoracic Aortopathy (GENIE-TA)
Name
Grant
Project
Elga de Vries and Inge Mulder
Equipment
Awake animal movement platform (Mobile Home Cage) and accompanying software
Pim van Oij and Marco Götte
Equipment
Smart-sync device provided by Northh Medical GmbH
Alexander Vlaar
Equipment
Two CytoCam Incident Dark Field (IDF) microcirculation cameras
Chantal van Opbergen
Postdoc
DNA damage and loss of nuclear envelope integrity as triggers of sudden cardiac death in the young
Melany Rios Morales
Postdoc
Unraveling fructose catabolism: Intestinal fructose-driven gluconeogenesis as an anti-obesity mechanism
Ilias Attaye
MD/PhD
Sex- and ethnic specific metabolism of dietary acid load in chronic kidney disease and cardio-metabolic disease
Jeroen Wessels
MD/PhD
The right heart phenotype and clinical outcomes in pulmonary hypertension
Vivian de Waard and Peter Hordijk
Out of the Box
Marfan syndrome iPSC-derived endothelial flow alignment and inflammation propagation
Louis Handoko and Joris de Groot
Out of the Box
The Epicardial Adipose Tissue/Myocardium IntEraction in Heart Failure with Preserved Ejection Fraction (EAT/MIE-HFpEF) study: a proteome analysis of the EAT secretome
Rio Juni and Marten Hoeksema
Out of the Box
Cardiac immuno-microvascular interface in heart failure with preserved ejection fraction
Anke Tijsen and Jan Willem Buikema
Out of the Box
Boosting hiPSC-CM genome-editing efficiency via small molecular GSK3 inhibition
Jan van den Bossche and Lily Jakulj
Out of the Box
Human peritoneal macrophage phenotype and its relation to systemic inflammation and cardiac function
Pim van Ooij and Lilian Meijboom
Out of the Box
Cardiac 4D flow MRI in pulmonary hypertension
Daniel van Raalye and Irene van Valkengoed
Out of the Box
Deciphering the Role of Sex Hormones in Kidney Function: A Comprehensive Proteomic Analysis
Noam Zelcer en Diederik Kuster
Out of the Box
The mystery of ApoB: A tale of cardiomyocytes and hepatocytes
Name
Grant
Project
Elena Rampanelli/Daniel van Raalte/Peter Henneman
Equipment
GeoMx Digital Spatial Profiler for spatial multiomics data
Abraham Hulst/Jeroen Hermanides, Denise Veelo/Daniel van Raalte/Alexander Vlaar
Equipment
Monitor for non-invasive measurement of urinary oxygenation
Jan Van den Bossche/Tyler Kirby
Equipment
Add-ons for a new AXR confocal microscope
Aida Llucià-Valldeperas/Frances de Man
Equipment
Extension for the FlexCell Tissue Train 3D culture system
Louis Handoko/Ot Bakersmans/Harm Jan Bogaard/Frances de Man
Equipment
Hemosphere monitor system for complete hemodynamic profiles in patients
Ilias Attaye
Postdoc
Identification of post-prandial gut-derived metabolites in cardio-metabolic health, with an emphasis on sex andethnic-specific associations
Lucía Cócera Ortega
Postdoc
Spatial cellular and transcriptomic map of Arrhythmogenic Cardiomyopathy
Mark Smits
Postdoc
Evaluating the role of sphinganine in GLP-1 secretion (‘SPHINGS’)
Pranav Bhagirath, Cardiology
Postdoc
Computational modelling combined with high-resolution 3D cardiac MRI in patients with ventricular arrhythmia: towards improving procedural efficacy of catheter ablation
Femke Piersma
Nursing Research
Complications of electrical cardioversion for atrial fibrillation, a step towards a predictive model
Peter Hordijk/Jeffrey Kroon
Out of the Box
The role of autophagy in healthy and inflamed 3D microvessels
Gijs Kooij/Jan Van den Bossche/Noam Zelcer
Out of the Box
Reprogramming foam cells with bioactive lipid mediator
Reinier Boon/Vincent Christoffels/Harsha Devalla
Out of the Box
Non-coding RNA control of a novel familial arrhythmia syndrome
Harm Jan Bogaard/Louis Handoko/Max Nieuwdorp/Erik Duijvelaar:
Out of the Box
EMPHOWER: Empagliflozin for Pulmonary Arterial Hypertension Patients with Exclusive Comorbidities
Frances de Man/Menno de Winther
Out of the Box
Creating a cell culture model to study the role of resident macrophages on cardiac adaptation to pressure overload
Bianca Brundel/Bas Boukens
Out of the Box
Atrial Fibrillation detection in Lmna mutant mice by an innovative ex vivo precision approach: dissection role of bio-electrical impairment
Elena Rampanelli/Daniel van Raalte
Out of the Box
Microbiome-induced expression of regenerating Islet-derived protein 1B to rescue loss of functional beta cells in diabetes and associated cardiovascular complications
Josine de Winter/Michel van Weeghel
Out of the Box
Unraveling a novel pathomechanism in a novel cardiomyopathy
Lily Jakulj/Marc Vervloet/Michiel Pegtel
Out of the Box
Peritoneal Dialysis Effluent-derived Extracellular Vesicles (PDE-EVs) to characterize cardiovascular risk in peritoneal dialysis
Four-Element Flame Photometer for biochemical analysis
Aart Nederveen/Pim van Ooij/Paul Groot
Equipment
AI compute node for advanced MR imaging techniques
Inge Mulder
Equipment
Long wavelength tunable laser for a multiphoton microscope
Jan Van den Bossche/Elga de Vries
Equipment
Biotek Cytation 5 upgrade for advanced imaging
Marco Götte
Equipment
12-lead ECG monitoring and recording system for MRI
Laura Bosmans
Postdoc
Targeting Glucocorticoid-Induced TNF Family-Related Protein (GITR) in macrophages to combat atherosclerosis: Identification of GITR-TRAF Small Molecule Inhibitors
Arnout Mieremet
Postdoc
UnHiDe Marfan: Uncovering Haploinsufficient and Dominant Negative iPSC phenotypes in Marfan Syndrome
Alwin Zweerink
MD/PhD
Conduction System Pacing - MECHanical ANd electrICal Study (CSP-MECHANICS)
Stefanie van Oostrum
Nursing Research
Pre-operative Nurse Assessment in Cardiothoracic Surgical Patients: A mixed-methods process evaluation of a complex intervention
Marja Holierook
Nursing Research
Is Edmonton Frailty Scale assessment before Transcatheter Aortic Valve Implantation a good predictor of negative outcomes?
Reinier Boon/Monika Gladka
Out of the Box
Single nuclei RNA sequencing to study the human diseased heart
Bianca Brundel/Anke Tijsen
Out of the Box
Culturing of LMNA hiPSC-derived atrial cardiomyocytes to dissect mechanism underlying atrial fibrillation
Vivian de Waard/Kakkhee Yeung/Connie Jimenez
Out of the Box
What drives the engine of the aortic aneurysm: identifying (phospho)proteins at the center of vascular smooth muscle cell contractile dysfunction
Esther Lutgens/Ed Eringa/Reinier Zandbergen
Out of the Box
SARS-CoV2 infection of perivascular adipose tissue and hyperinflammation in COVID-19
Max Nieuwdorp/Elena Rampanelli/Barbara Verhaar/Daniel van Raalte
Out of the Box
The role of gut microbiota and its metabolites in blood pressure regulation
Name
Grant
Project
Fleur Tjong
Postdoc
Deep learning for identification of ICD patients at risk of lethal cardiac arrhythmias: The deep risk ICD Study
Annette Neele
Postdoc
Targeting the Polycomb Repressive Complex 2 (PRC2) in atherosclerosis by small molecule drugs
Najim Lahrouchi
MD/PhD
Personalized medicine for patients with the long QT syndrome
Nick van Es
MD/PhD
Combining clinical and genetic risk factors to identify cancer patients at high risk of arterial and venous thromboembolism: a new challenge in cardio-oncology
Menno de Winther/Jan Van den Bossche/Max Nieuwdorp/Maarten Soeters
Out of the Box
Promoting immune health by intermittent fasting: taming the monocytes?
Liffert Vogt/Majon de Boer/Marie van Dijk
Out of the Box
Investigating placental non-osmotic sodium buffering across pregnancy
Meeike Kusters/Barbara Hutten
Out of the Box
The search for new biomarkers in risk stratification: towards a tailor made treatment for young patients with familial hypercholesterolemia
Harm Jan Bogaard/Harry Buller/Josien Smits/Azar Kianzad
Out of the Box
Detecting CTEPH with educated platelets: a case-control study