With the start of Amsterdam Cardiovascular Sciences (ACS) research institute on the 1st of January 2016, ACS provided funds to support talented ACS researchers and to stimulate collaboration between ACS researchers within Amsterdam UMC. Each year several calls have been organized for ACS researchers at different stages of their careers.
Each year, ACS organizes grant rounds for the Postdoc grant (€70,000), MD/PhD grant (€25,000) and the Out of the Box (OOTB) grant (€25,000). The Postdoc and MD/PhD grants are for excellent young basic and clinical researchers, respectively, and aim to support talented ACS researchers. The Postdoc grant provides the opportunity to obtain postdoc experience for a period of one year in a prestigious research center abroad. The MD/PhD grant covers one day a week protected research time for a two-year post-doctoral project for medical specialists in training. The OOTB grant aims at supporting ACS project leaders to set up new collaborations between Amsterdam UMC locations AMC and VUmc and to strengthening joint future grant applications. The Nursing Research grant (€12,500) was introduced in 2021 and allows nurses with a Master’s degree to have 1.5 day a week protected research time in order to prepare a PhD trajectory in the cardiovascular field in combination with clinical duties as a nurse.
Two laureates from 2016 tell what the ACS grant has brought them.
Marten Hoeksema - ACS Postdoc grant 2016
The ACS Postdoc fellowship allowed me to perform my post-doc in the lab of Professor Glass, a world expert in macrophages and gene regulation. As the result of the vibrant and collaborative environment at UC San Diego, I have been able to master novel state-of-the-art genetic techniques and analysis tools, and to expand my scientific network. During my time here, I have identified key transcription factors for activation of both anti-inflammatory and pro-inflammatory gene enhancers in macrophages, fundamental information that we can use for inflammatory and cardiovascular diseases. Based on these findings, I applied for additional research grants and was recently awarded with the American Heart Association Postdoc grant and a Marie Curie Individual Fellowship.
Marten Hoeksema: I highly recommend young researchers apply for the ACS postdoc grant to visit a lab abroad. It has been a great life experience for me, as I have learned so much both inside and outside the lab!
Ronak Delewi – ACS MD/PhD grant 2016
During my residency in Cardiology at the AMC, I remained captivated by cardiovascular research in the hope of improving clinical outcomes on a larger scale. Although I am a devoted physician, I missed having dedicated research time. As such, this ACS MD/PhD grant provided the perfect combination for my last years of training. I spent this time performing research in the field of transcatheter aortic valve implantation, supervising PhD students and also set up new research ideas and grants. It truly was the foundation for the future, where I will hopefully be able to further combine the love for research and interventional cardiology.
Laureates 2022
| Name | Grant | Project |
|---|---|---|
| Elena Rampanelli/Daniel van Raalte/Peter Henneman | Equipment | GeoMx Digital Spatial Profiler for spatial multiomics data |
| Abraham Hulst/Jeroen Hermanides, Denise Veelo/Daniel van Raalte/Alexander Vlaar | Equipment | Monitor for non-invasive measurement of urinary oxygenation |
| Jan Van den Bossche/Tyler Kirby | Equipment | Add-ons for a new AXR confocal microscope |
| Aida Llucià-Valldeperas/Frances de Man | Equipment | Extension for the FlexCell Tissue Train 3D culture system |
| Louis Handoko/Ot Bakersmans/Harm Jan Bogaard/Frances de Man | Equipment | Hemosphere monitor system for complete hemodynamic profiles in patients |
| Ilias Attaye | Postdoc | Identification of post-prandial gut-derived metabolites in cardio-metabolic health, with an emphasis on sex andethnic-specific associations |
| Lucía Cócera Ortega | Postdoc | Spatial cellular and transcriptomic map of Arrhythmogenic Cardiomyopathy |
| Mark Smits | Postdoc | Evaluating the role of sphinganine in GLP-1 secretion (‘SPHINGS’) |
| Pranav Bhagirath, Cardiology | Postdoc | Computational modelling combined with high-resolution 3D cardiac MRI in patients with ventricular arrhythmia: towards improving procedural efficacy of catheter ablation |
| Femke Piersma | Nursing Research | Complications of electrical cardioversion for atrial fibrillation, a step towards a predictive model |
| Peter Hordijk/Jeffrey Kroon | Out of the Box | The role of autophagy in healthy and inflamed 3D microvessels |
| Gijs Kooij/Jan Van den Bossche/Noam Zelcer | Out of the Box | Reprogramming foam cells with bioactive lipid mediator |
| Reinier Boon/Vincent Christoffels/Harsha Devalla | Out of the Box | Non-coding RNA control of a novel familial arrhythmia syndrome |
| Harm Jan Bogaard/Louis Handoko/Max Nieuwdorp/Erik Duijvelaar: | Out of the Box | EMPHOWER: Empagliflozin for Pulmonary Arterial Hypertension Patients with Exclusive Comorbidities |
| Frances de Man/Menno de Winther | Out of the Box | Creating a cell culture model to study the role of resident macrophages on cardiac adaptation to pressure overload |
| Bianca Brundel/Bas Boukens | Out of the Box | Atrial Fibrillation detection in Lmna mutant mice by an innovative ex vivo precision approach: dissection role of bio-electrical impairment |
| Elena Rampanelli/Daniel van Raalte | Out of the Box | Microbiome-induced expression of regenerating Islet-derived protein 1B to rescue loss of functional beta cells in diabetes and associated cardiovascular complications |
| Josine de Winter/Michel van Weeghel | Out of the Box | Unraveling a novel pathomechanism in a novel cardiomyopathy |
| Lily Jakulj/Marc Vervloet/Michiel Pegtel | Out of the Box | Peritoneal Dialysis Effluent-derived Extracellular Vesicles (PDE-EVs) to characterize cardiovascular risk in peritoneal dialysis |
Laureates 2021
| Name | Grant | Project |
|---|---|---|
| Marjet Oppelaar/Rosa Wouda/Liffert Vogt /Marc Vervloet | Equipment | Four-Element Flame Photometer for biochemical analysis |
| Aart Nederveen/Pim van Ooij/Paul Groot | Equipment | AI compute node for advanced MR imaging techniques |
| Inge Mulder | Equipment | Long wavelength tunable laser for a multiphoton microscope |
| Jan Van den Bossche/Elga de Vries | Equipment | Biotek Cytation 5 upgrade for advanced imaging |
| Marco Götte | Equipment | 12-lead ECG monitoring and recording system for MRI |
| Laura Bosmans | Postdoc | Targeting Glucocorticoid-Induced TNF Family-Related Protein (GITR) in macrophages to combat atherosclerosis: Identification of GITR-TRAF Small Molecule Inhibitors |
| Arnout Mieremet | Postdoc | UnHiDe Marfan: Uncovering Haploinsufficient and Dominant Negative iPSC phenotypes in Marfan Syndrome |
| Alwin Zweerink | MD/PhD | Conduction System Pacing - MECHanical ANd electrICal Study (CSP-MECHANICS) |
| Stefanie van Oostrum | Nursing Research | Pre-operative Nurse Assessment in Cardiothoracic Surgical Patients: A mixed-methods process evaluation of a complex intervention |
| Marja Holierook | Nursing Research | Is Edmonton Frailty Scale assessment before Transcatheter Aortic Valve Implantation a good predictor of negative outcomes? |
| Reinier Boon/Monika Gladka | Out of the Box | Single nuclei RNA sequencing to study the human diseased heart |
| Bianca Brundel/Anke Tijsen | Out of the Box | Culturing of LMNA hiPSC-derived atrial cardiomyocytes to dissect mechanism underlying atrial fibrillation |
| Vivian de Waard/Kakkhee Yeung/Connie Jimenez | Out of the Box | What drives the engine of the aortic aneurysm: identifying (phospho)proteins at the center of vascular smooth muscle cell contractile dysfunction |
| Esther Lutgens/Ed Eringa/Reinier Zandbergen | Out of the Box | SARS-CoV2 infection of perivascular adipose tissue and hyperinflammation in COVID-19 |
| Max Nieuwdorp/Elena Rampanelli/Barbara Verhaar/Daniel van Raalte | Out of the Box | The role of gut microbiota and its metabolites in blood pressure regulation |
Laureates 2020
| Name | Grant | Project |
|---|---|---|
| Fleur Tjong | Postdoc | Deep learning for identification of ICD patients at risk of lethal cardiac arrhythmias: The deep risk ICD Study |
| Annette Neele | Postdoc | Targeting the Polycomb Repressive Complex 2 (PRC2) in atherosclerosis by small molecule drugs |
| Najim Lahrouchi | MD/PhD | Personalized medicine for patients with the long QT syndrome |
| Nick van Es | MD/PhD | Combining clinical and genetic risk factors to identify cancer patients at high risk of arterial and venous thromboembolism: a new challenge in cardio-oncology |
| Menno de Winther/Jan Van den Bossche/Max Nieuwdorp/Maarten Soeters | Out of the Box | Promoting immune health by intermittent fasting: taming the monocytes? |
| Liffert Vogt/Majon de Boer/Marie van Dijk | Out of the Box | Investigating placental non-osmotic sodium buffering across pregnancy |
| Meeike Kusters/Barbara Hutten | Out of the Box | The search for new biomarkers in risk stratification: towards a tailor made treatment for young patients with familial hypercholesterolemia |
| Harm Jan Bogaard/Harry Buller/Josien Smits/Azar Kianzad | Out of the Box | Detecting CTEPH with educated platelets: a case-control study |
Laureates 2019
| Name | Grant | Project |
|---|---|---|
| Muriel Grooteman/Frans van Ittersum | Equipment | Sodium receiver coil for body imaging on the 7 Tesla MRI scanner |
| Daniel van Raalte/Max Nieuwdorp | Equipment | High Performance Liquid Chromatography (uHPLC) system |
| Erik Serné/Ed Eringa | Equipment | PeriCam PSI NR |
| Jan Van den Bossche/Elga de Vries | Equipment | Cytation 1 cell imaging device |
| Marco Götte/Aart Jan Nederveen | PhD | MRI guided cardiac ablation in explanted beating pig hearts |
| Vivian de Waard/Dimitra Micha | PhD | Genetic Characteristics of Marfan Patients dictate aneurysm severity and treatment |
| Bianca Brundel/Riekelt Houtkooper | OOTB-2 | Staging of clinical atrial fibrillation: metabolomics as diagnostic tool? |
| Elga de Vries/Carlie de Vries | OOTB-2 | Four and a half lim domain 2 (fhl2) regulates vascular barrier function in aorta and brain microvasculature |
| Ed Eringa/Jeffrey Kroon | OOTB-2 | Get to the heart of the matter: mapping metabolic reprogramming in valvular interstitial cells in order to combat aortic valve stenosis |
| Peter Hordijk/Ed van Bavel | OOTB-2 | Endothelial-cardiomyocyte communication through electrical coupling |
| Arjan Houweling/Vivian de Waard | OOTB-2 | Unravelling modifier genes responsible for variable clinical presentation of aortic complications in marfan syndrome |
| Mathilde Rivaud/Veronique Meijborg/Paul Wijnker | OOTB-2 | Effects of modifying electrical diastole on diastolic function |
| Eliane Wenstedt/Liffert Vogt/Niels Heemskerk/Jan van den Bossche | OOTB-2 | Does salt consumption drive leukocyte infiltration in humans |
| Pranav Bhagirath | MD/PhD | Defining atrial cardiomyopathy using serial evaluation with cardiac magnetic resonance imaging and biomarkers in patients with atrial fibrillation (DESCRIBE-AF trial) |
| Jouke Bokma | MD/PhD | To optimize timing of pulmonary valve replacement in adults with tetralogy of Fallot |
| Camiel de Roij van Zuijdewijn | MD/PhD | Peri- and intradialytic hemodynamic stability in patients treated with various dialysis modalities |
| Fleur Tjong | MD/PhD | Deep learning models for development of novel tools for identification of patients at risk of complications and shock therapy following pacemaker and ICD implantation |
| Daniël van Raalte/Carlie de Vries | OOTB | LIM-domain only protein FHL2 secreted? An unexpected finding requiring further research. |
| Jurjan Aman/Stephan Huveneers | OOTB | Linking early endothelial barrier injury to vascular remodelling: a role for SOX17 in the onset of pulmonary hypertension. |
| Vivian de Waard/Dimitra Micha | OOTB | The two genetic Marfan subtypes deserve a mouse model for preclinical studies. |
| Esther Creemers/Bianca Brundel | OOTB | Uncovering atrial cardiomyocyte proteostais derailment and atrial fibrillation |
| Roddy Walsh | Postdoc | Identifying genetic factors that influence variable penetrance and disease expressivity in hypertrophic cardiomyopathy |
| Natalija Bogunovic | Postdoc | PRDM protein family as novel transcriptional regulators of aortic aneurysm pathology |
Laureates 2018
| Name | Grant | Project |
|---|---|---|
| Reinier Boon/Stephan Huveneers | PhD | Towards Protective Building Blocks for the Endothelial Barrier |
| Max Nieuwdorp/Majon Muller/ Han Levels/Mike Peters | PhD | The gut microbiome and aging of the vascular system |
| Menno de Winther/Jan van de Bossche/ Michel van Weeghel | PhD | Local immunometabolites shape inflammatory macrophages and atherosclerosis progression |
| Ed Eringa/Gustav Strijkers/Carlie de Vries | Equipment | Contrast ultrasonography for identifying and understanding perfusion defects in organ failure |
| Marco Götte/Alexander Vonk | Equipment | Mri-Compatible Multi-Channel Hemodynamic Monitoring System, Philips In Vivo MR Expression 400 |
| Coert Zuurbier/Jolanda van der Velden | OOTB | Targeting genetic heart disease with diabetes medication |
| Carol Ann Remme/Diederik Kuster | OOTB | Keeping cardiomyocytes dynamic and exciting: a novel approach to prevent mechanical and electrical dysfunction in cardiomyopathy |
| Noam Zelcer/Elga de Vries | OOTB | The nuclear receptors Liver X Receptors (LXRS) couple lipid metabolism to control of vascular integrity of the blood-brain barrier |
| Louis Handoko/Ot Bakermans | OOTB | TrimetaziDine as a Performance-enhancING drug in heart failure with preserved ejection fraction (DoPING-HFpEF) |
| Leo Heunks/Coen Ottenheijm/Janneke Horn | OOTB | Positive end expiratory pressure (PEEP) applied during mechanical ventilation as a novel mechanism to explain critical illness associated diaphragm weakness |
| Yu-Sok Kim/Johannes van Lieshout | OOTB | Effect of treatment modality on cerebrovascular control and cognitive function in patients with end-stage renal disease - hemodiafiltration vs. hemodialysis |
| Peter van Tintelen/Bianca Brundel | OOTB | A giant molecule underlying a major disease? |
| Ibrahim Danad | MD/PhD | CT perfusion Imaging for the assessment of functionally relevant CAD as Indexed by 15O[H2O] PET and Fractional Flow Reserve |
| Rik Olde Engberink | MD/PhD | The endothelial surface layer as orchestrator of interstitial Na+ homeostasis |
| Ralf Harskamp | MD/PhD | Triage in acute chest pain evaluation in primary care (TRACE) |
| Thijs van Mens | MD/PhD | Defining the role of gut microbiome pathways in venous thromboembolism pathophysiology |
| Debbie Kalkman | Postdoc | Prevention of in-stent restenosis in diabetic patients with coronary artery disease |
| Marit Wiersma | Postdoc | LMNA and DES mutations: undissolved role for cardiomyocyte proteostasis and AF promotion in familial atrial fibrillation |
| Paul Wijnker | Postdoc | A disturbed redox-balance triggers cardiac disease in inherited cardiomyopathy |
| René Musters | Equipment | Extension of AO/2M Nikon A1-DUS MULTISPECTRALE-DETECTOR, improvement of platform functionality |
| Diederik Kuster/Charissa van den Brom | Equipment | Fluorescent Western blot imager |
| Yu-Sok Kim/Frans van Ittersum | Equipment | Trans Cranial Doppler |
| Yu-Sok Kim/Frans van Ittersum | Equipment | Servo-controlled finger plethysmograph (Nexfin® or ClearSight EV1000®) |
Laureates 2017
| Name | Grant | Project |
|---|---|---|
| Peter Hordijk/Stephan Huveneers | PhD | The Push and Pull of (dys)balanced endothelial integrity |
| Reinier Boon/Riekelt Houtkooper | PhD | The role of long non-coding RNAs in regulating cardiac metabolism during aging |
| Carlie de Vries/Ed Eringa/Daniel van Raalte/Max Nieuwdorp | PhD | Prevention of aging-related type 2 diabetes and vascular disease through LIM-domain only protein FHL2 |
| René Musters | Equipment | Extension of the Leica TCS SP8 STED 3X platform with a OKO-labs microscopy environment, with climate control and live-cell stage incubator together with a Navigator-stage-module extension of software possibilities |
| Peter Hordijk/Carlie de Vries | Equipment | 96 well ECIS machine and Reader (extension) |
| Harm Jan Bogaard/Robert Szulcek | Equipment | GentleMACS tissue dissociator with MultiMACS 24 cell separator |