Tager Lecture Alexander Bartelt

Theme Metabolism

Target audience Researchers

Language English

General

Each year, the AGEM research institute organizes a seminar series focused on metabolism: the Tager Lectures. These lectures are named after Professor Joseph Tager, who made important contributions to Fabry, Pompe and Gaucher disease and had a major impact on our understanding of peroxisomal diseases. He was chairman of the Biochemistry Department at the University of Amsterdam (1980-1991).

Prof. Dr . Alexander Bartelt

On Thursday June 19th, the Tager seminar series will continue with a new lecture by Prof. Dr. Alexander Bartelt, who is a full professor and inaugural chair of Translational Nutritional Medicine at Technical University Munich, Germany.

Lecture topic

The Metabolic Physiology of Proteostasis

Proteostasis, the regulation of protein synthesis, folding, and degradation, is an evolutionary conserved key prerequisite of cellular adaption. Next to the interplay of the unfolded protein response and autophagy the ubiquitin-proteasome system is linked to aging and various diseases.

Examining the molecular mechanisms underlying proteasome function and proteostasis highlights the adaptive role of protein degradation in physiological challenges such as exercise or thermogenesis, but also proteotoxic stress in cardiometabolic diseases such as obesity, diabetes or atherosclerosis.