This is associated with injury, wounds, and loss of bone and muscle tissue and strength. On the other hand, sports- and accident-related (traumatic) injuries are increasingly common. This often results in altered structure and mechanical function of musculoskeletal/skin tissues, which need to be repaired or adapted.
Overall Aim
Successful regeneration or adaptation of muscle, tendon, bone, cartilage and skin requires optimal cellular conditions. Those conditions are determined by systemic factors, such as biochemical changes in the circulation that alter the niche of the cells, and by local factors, such as external loads, niche stiffness and architecture, availability of nutrients, oxygen, as well as presence or absence of signalling molecules such as growth factors, cytokines, and steroids.
This program integrates molecular biology, cell physiology, chemistry, biophysics, bioengineering, and medicine across various levels of organization (from cell to organ to whole organism and back) to study structure-function relationships, adaptation and regeneration of musculoskeletal tissues. For innovative solutions in clinical cases there is a need in intensive collaboration between researchers and clinicians. One of the aims of AMS this program is to develop a platform on which researchers, engineers and clinicians work multidisciplinary on clinical issues.
Program Board
- Dr. Nathalie Bravenboer, Amsterdam UMC, location VUmc (Program director);
- Dr. Marco Helder, Amsterdam UMC, location VUmc (Program deputy director);
- Professsor dr. Richard Jaspers, Faculty of Behavioural and Movement Sciences, VU Amsterdam;
Professor dr. Jenneke Klein-Nulend, ACTA;
- Dr. Huub Maas, Faculty of Behavioural and Movement Sciences, VU Amsterdam;
- Dr. Ibrahim Korkmaz ECR, Amsterdam UMC, location VUmc.
Program Members
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Adriaan Lammertsma PROF.DR., (Principal Investigator)
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Anne-Marie van Dam DR., (Principal Investigator)
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Bernard Smilde MSC.
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Bert Schulten PROF.DR., (Principal Investigator)
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Derk Jager DR. Mpros RCSed DMD
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Dimitra Micha , (Principal Investigator)
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Elisabet Farre Guasch
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Esther Middelkoop PROF.DR., (Principal Investigator)
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Frank Niessen DR., (Principal Investigator)
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H Maas
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Halil Ibrahim Korkmaz Dr.
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Hanna C. Willems PhD
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Irene van der Horst-Bruinsma PROF.DR., (Principal Investigator)
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Irit Vahav
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Jaco Suijker DRS.
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Lodewijk Stroy
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Maarten Vehmeijer DRS.
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Marco Helder DR., (Principal Investigator)
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Marco Ritt PROF.DR.
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Marelise Eekhoff DR., (Principal Investigator)
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Margriet Mullender DR., (Principal Investigator)
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Marieke J. Henstra MD
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Marije C. Koele MD
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Marjolijn Gilijamse DRS.
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Maureen van Eijnatten MSC.
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Merle R. Schene
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Miryam C. Obdeijn
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Nathalie Bravenboer DR., (Principal Investigator)
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Paul van Zuijlen PROF.DR., (Principal Investigator)
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Peter Huijing
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Peter Kloen Prof. PhD
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Pieter Raijmakers DR.
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RT Jaspers
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Simon D. Strackee PhD
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Theo Smit Prof. MEng PhD, (Principal Investigator)
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Tim Forouzanfar PROF.DR., (Principal Investigator)
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Tyler Kirby PhD
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Willem Lems PROF.DR., (Principal Investigator)