The Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects study was initiated in April 2009 as an observational retrospective pharmacy-based cohort study. The aim was to examine asthma treatment response.

The Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects (PACMAN) study was initiated in April 2009 as an observational retrospective pharmacy-based cohort study. Children with a reported regular use of asthma medication (aged 4-12 years) were included in Dutch community pharmacies in order to study factors associated with asthma treatment response.

Data collection included: respiratory symptoms, medication use behavior, medication histories, inhalation technique, exhaled NO measurements (FeNO) and saliva samples for DNA extraction (GWAS data are available). Data is available for > 900 children. A small subset of children (n = 37) have been extensively phenotyped during a clinical follow-up visit (including exhaled breath analysis, atopy measures).

Data collection has stopped since 2016. The data are ocassionally used for research.

You find more information on the PACMAN cohort study in their article (in Dutch).

APH contact person: Susanne Vijverberg & Anke -Hilse Maitland van der Zee