Research highlights | Amsterdam UMC

Exposome-NL study The Exposome-NL study is a large epidiomological study which comprises many traits of individuals alongside environmental variables.

Ongoing

Optimization of exerCise Therapy in patients with knee Osteoarthritis in a Primary care Setting (OCTOPuS-study): a Randomized Controlled Trial Optimizing current treatment of exercise therapy in patients with knee osteoarthritis by applying a stratified approach.and evaluating the (cost-) effectiveness of stratified exercise therapy.

Ongoing

Metabolic Dysfunction and Anabolic Resistance during Inactivity and Systemic Inflammation In this translational project we aim to investigate the molecular mechanisms of physical inactivity and systemic inflammation on skeletal muscle metabolism.

Ongoing

(Cost-)effectiveness of the transmural trauma care model Assessing the (cost-)effectiveness of the improved version of the TTCM as compared to usual care in a multicenter trial with controlled before-and-after design.

Ongoing

Targeting hepatic bile salt uptake to treat cholestasis or the metabolic syndrome AGEM In this project we aim to understand the role of bile acids (and its dynamics) in energy, fat and glucose homeostasis, and in inflammation.

Ongoing

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Isolation of 403 monoclonal antibodies from COVID-19 patients revealed convergent gene usage and multiple target epitopes

Ongoing

Single domain antibody targeting of the CD1d monomorphic antigen-presenting molecule induces potent anti-tumour activity Camelid-derived single domain antibodies (VHH)5 specific for the human MHC class I-like molecule CD1d can modulate the function of CD1d-restricted T cell populations.

Ongoing

Selective tumor antigen vaccine delivery to human CD169+ antigen presenting cells using ganglioside-liposomes Current immunotherapies only benefit a minority of cancer patients. We need new approaches to boost patients’ anti-tumor immune responses.

Ongoing

Germline biomarkers of melanoma immunotherapy: an international consortium Biomarkers that predict immunotherapy treatment success or risk of toxicity are urgently needed to increase the clinical benefit for metastatic melanoma patients.

Ongoing

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