How smooth muscle cells shape atherosclerosis: discovery of the regulator that keeps them in checkA new international study, published in Nature Cardiovascular Research, has uncovered a crucial role for the gene PRDM16 in regulating smooth muscle cell identity and atherosclerotic plaque composition. The findings, published in collaboration with leading institutions including the University of Pennsylvania, Columbia University, University of Virginia, Mayo Clinic, and TU Munich, open new avenues for cardiovascular research and therapy.
PAIS TOPIC 101 | With Brent Appelman At the Amsterdam institute for Immunology and Infectious diseases (AI&I), we are proud of the diverse and impactful research taking place across our institute. To provide direction and focus, we have identified three focus areas where we aim to stimulate and organize research for greater impact: PAIS, Immunomonitoring, and Vaccination.
In Q3 2025, the spotlight is on Post-Acute Infection Syndrome (PAIS). In this article, written in collaboration with AI&I researcher Brent Appelman, we explore the topic in depth.
Living environment plays a role in the risk of cardiovascular diseasePeople who live in neighborhoods with many unhealthy eating establishments and few opportunities for walking, cycling, or exercising have a higher risk of cardiovascular disease. This risk is almost five percent higher, according to large-scale research conducted by UMC Utrecht and Amsterdam UMC. The results of the study were recently published in The Lancet Regional Health Europe.
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