Amsterdam Gastroenterology Endocrinology Metabolism

Joep Grootjans

MD PhD

Other Academic Staff, Amsterdam Gastroenterology Endocrinology Metabolism Medical Specialist, Gastroenterology and Hepatology Other Academic Staff, Tytgat Institute for Liver and Intestinal Research

Specialization

Gastroenterology. Mucosal immunology in inflammatory Bowel Disease

Focus of research

My research focuses on understanding the pathogenesis of immune-based gastrointestinal diseases with a main focus on inflammatory bowel disease (IBD) and cancer. The ultimate goal is to find new therapies for these diseases.

Latest publications

Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
Duan, J., Matute, J. D., Unger, L. W., Hanley, T., Schnell, A., Lin, X., Krupka, N., Griebel, P., Lambden, C., Sit, B., Grootjans, J., Pyzik, M., Sommer, F., Kaiser, S., Falk-Paulsen, M., Grasberger, H., Kao, J. Y., Fuhrer, T., Li, H., Paik, D., & 14 othersLee, Y., Refetoff, S., Glickman, J. N., Paton, A. W., Bry, L., Paton, J. C., Sauer, U., Macpherson, A. J., Rosenstiel, P., Kuchroo, V. K., Waldor, M. K., Huh, J. R., Kaser, A. & Blumberg, R. S., 9 May 2023, In: Immunity. 56, 5, p. 1115-1131.e9
Research output: Contribution to journal › Article › Academic › peer-review
Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila
Matute, J. D., Duan, J., Flak, M. B., Griebel, P., Tascon-Arcila, J. A., Doms, S., Hanley, T., Antanaviciute, A., Gundrum, J., Mark Welch, J. L., Sit, B., Abtahi, S., Fuhler, G. M., Grootjans, J., Tran, F., Stengel, S. T., White, J. R., Krupka, N., Haller, D., Clare, S., & 11 othersLawley, T. D., Kaser, A., Simmons, A., Glickman, J. N., Bry, L., Rosenstiel, P., Borisy, G., Waldor, M. K., Baines, J. F., Turner, J. R. & Blumberg, R. S., 2 Jan 2023, In: Journal of Experimental Medicine. 220, 1, e20211938.
Research output: Contribution to journal › Article › Academic › peer-review
Superior Effectiveness of Tofacitinib Compared to Vedolizumab in Anti-TNF-experienced Ulcerative Colitis Patients: A Nationwide Dutch Registry Study
Initiative on Crohn and Colitis, Jan 2023, In: Clinical Gastroenterology and Hepatology. 21, 1, p. 182-191.e2
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Amsterdam Gastroenterology Endocrinology Metabolism

Joep Grootjans

Specialization

Focus of research

Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut

Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila

Superior Effectiveness of Tofacitinib Compared to Vedolizumab in Anti-TNF-experienced Ulcerative Colitis Patients: A Nationwide Dutch Registry Study