Richie Goulding (VU Amsterdam) has been awarded a grant of ∼€420,000 in the NWO Open Competition Domain for his research project titled 'Age-Related Skeletal Muscle Decline: Integrative Insights from Physiology to Molecular Regulation'.

The research project aims to unravel the mechanisms underlying age-related skeletal muscle dysfunction. Using innovative techniques involving near-infrared spectroscopy (NIRS), as well as advanced microscopy and phosphoproteomics, we will assess mitochondrial function, muscle diffusive capacity, the muscle structures underlying these functions and their molecular regulation in young, middle-aged, and elderly individuals. Additionally, we will investigate the effects of endurance training on mitochondrial function in middle-aged subjects. By understanding how ageing impacts muscle function and exploring exercise interventions, we aim to contribute to both scientific knowledge and potential clinical applications for improving health outcomes in ageing populations.