Theme Metabolism
Target audience Researchers
Language English

General

Each year, the AGEM research institute organizes a seminar series focused on metabolism: the Tager Lectures. These lectures are named after Professor Joseph Tager, who made important contributions to Fabry, Pompe and Gaucher disease and had a major impact on our understanding of peroxisomal diseases. He was chairman of the Biochemistry Department at the University of Amsterdam (1980-1991).

Prof. Charna Dibner

On Thursday April 17th, the Tager seminar series will continue with a new lecture by Prof. Charna Dibner, who works as Associate Professor, at the the University of Geneva, and Group Leader of the Laboratory of Circadian Endocrinology in the Division of Endocrinology, Diabetes, Hypertension and Nutrition.

The research in the Dibner lab has been funded by Swiss National Science Foundation, European Foundation of Studies of Diabetes (EFSD), Swiss Cancer League, ISREC Foundation, Leenaards Foundation, Velux Foundation, and many more competitive grants and awards.

Masterclass with Prof. Charna Dibner

Prior to the lecture, professor Dibner will give a masterclass for PhD
Students and Post Docs. For more information on the masterclass, please check out the event page. Don't miss this unique opportunity to present your research and discuss it with professor Dibner.

Lecture topic - Circadian clocks: A driving force of rhythmin physiology and metabolism

The circadian clock system has evolved by most organisms as an anticipatory mechanism driving rhythmic oscillations of physiology with approximately 24-hour cycles (circa diem, from Latin “about a day”). A key function of the circadian timing system is to orchestrate metabolism in different organs according to the needs imposed by rest-activity cycles. Light exposure during the night, late meals, and reduced sleep hours associated with modern lifestyle desynchronize intrinsic clocks from environmental cycles.

Type 2 diabetes mellitus (T2D), a major public health challenge today, is one of the consequences of circadian misalignment. Our works demonstrated that circadian oscillators in metabolic organs ensure temporal orchestration of lipid landscape impacting on the organ function, which is perturbed in T2D patients in a time- and tissue-specific manner. We are eager to dissect the molecular pathways linking the clock and lipid landscape disruption to the pathogenesis of T2D, and to explore its therapeutic potential.

Learn more about her

Date and Location

Time From 12:00 to 13:00
Start date Thursday, April 17, 2025
Location Vrijzaal, location AMC, Amsterdam UMC
Lunch is included!

Costs and registration

Free of charge and registration not needed.

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