Focus of research
Research focus on biology and treatment of B-cell malignancies with chronic lymphocytic leukemia (CLL) as main disease serving as a B-cell malignancy model.
Research involves both pre-clinical (cellines, primary CLL cells, mouse models) as well as clinical (phase 1, 2, 3) studies.
The studies are divided in three reserach programs around the central theme: development of, circumvention of and novel strategies for (development of) chemorefractory disease
1. Genetic abberations
2. Intracellular signaling
3. Cross-talk with microenvironment