Amsterdam institute for Immunology and Infectious diseases

Sergey Nezhentsev

AII - Immunology AII - Infectious Diseases Full Professor, Molecular Cell Biology and Immunology

Specialization

Focus of research

My lab studies human genome aiming to dissect molecular mechanisms of susceptibility to infections and translate these findings into novel therapies. We have two programmes that focus on (1) primary immunodeficiencies and (2) mechanisms of host-pathogen interaction in tuberculosis.

Key publications
Latest publications

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
Cuchet-Lourenço, D., Eletto, D., Wu, C., Plagnol, V., Papapietro, O., Curtis, J., Ceron-Gutierrez, L., Bacon, C. M., Hackett, S., Alsaleem, B., Maes, M., Gaspar, M., Alisaac, A., Goss, E., AlIdrissi, E., Siegmund, D., Wajant, H., Kumararatne, D., AlZahrani, M. S. & Arkwright, P. D. & 3 others, Abinun, M., Doffinger, R. & Nejentsev, S., 24 Aug 2018, In: Science. 361, 6404, p. 810-813 4 p.
Research output: Contribution to journal › Article › Academic › peer-review
Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
Angulo, I., Vadas, O., Garçon, F., Banham-Hall, E., Plagnol, V., Leahy, T. R., Baxendale, H., Coulter, T., Curtis, J., Wu, C., Blake-Palmer, K., Perisic, O., Smyth, D., Maes, M., Fiddler, C., Juss, J., Cilliers, D., Markelj, G., Chandra, A. & Farmer, G. & 24 others, Kielkowska, A., Clark, J., Kracker, S., Debré, M., Picard, C., Pellier, I., Jabado, N., Morris, J. A., Barcenas-Morales, G., Fischer, A., Stephens, L., Hawkins, P., Barrett, J. C., Abinun, M., Clatworthy, M., Durandy, A., Doffinger, R., Chilvers, E. R., Cant, A. J., Kumararatne, D., Okkenhaug, K., Williams, R. L., Condliffe, A. & Nejentsev, S., 15 Nov 2013, In: Science. 342, 6160, p. 866-71 6 p.
Research output: Contribution to journal › Article › Academic › peer-review
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration
Curtis, J., Luo, Y., Zenner, H. L., Cuchet-Lourenço, D., Wu, C., Lo, K., Maes, M., Alisaac, A., Stebbings, E., Liu, J. Z., Kopanitsa, L., Ignatyeva, O., Balabanova, Y., Nikolayevskyy, V., Baessmann, I., Thye, T., Meyer, C. G., Nürnberg, P., Horstmann, R. D. & Drobniewski, F. & 3 others, Plagnol, V., Barrett, J. C. & Nejentsev, S., May 2015, In: Nature genetics. 47, 5, p. 523-527 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Impact of COVID-19 disease and vaccination on dermatological immune-mediated inflammatory diseases atopic dermatitis, psoriasis, and vitiligo: a Target2B! substudy
van Buchem-Post, N. F., Ouwerkerk, W., Stalman, E. W., van Dam, K. P. J., Wieske, L., Bekkenk, M. W., Wolkerstorfer, A., Spuls, P., Musters, A. H., Bosma, A. L., Hijnen, D.-J., Eftimov, F., Luiten, R. M., T2B! immunity against SARS-CoV-2 study group & Hilhorst, M. L., Apr 2025, In: Journal of Dermatology. 52, 4, p. 624-633 10 p.
Research output: Contribution to journal › Article › Academic › peer-review
T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination
T2B! immunity against SARS-CoV-2 study group, Verstegen, N. J. M., Hagen, R. R., Kreher, C., Kuijper, L. H., van den Dijssel, J., Ashhurst, T., Kummer, L. Y. L., Cabeza, V. P., Steenhuis, M., Duurland, M. C., de Jongh, R., van der Schoot, C. E., Konijn, V. A. L., Mul, E., Kedzierska, K., van Dam, K. P. J., Stalman, E. W., Boekel, L. & Wolbink, G. & 31 others, Tas, S. W., Killestein, J., Rispens, T., Wieske, L., Kuijpers, T. W., Eftimov, F., van Kempen, Z. L. E., van Ham, S. M., ten Brinke, A., van de Sandt, C. E., vd Kooi, A. J., Raaphorst, J., Zwinderman, A. H. K., Löwenberg, M., Volkers, A. G., D'Haens, G. R. A. M., Takkenberg, R. B., Spuls, P. I., Bekkenk, M. W., Musters, A. H., Post, N. F., Bosma, A. L., Hilhorst, M. L., Vegting, Y., Bemelman, F. J., Fernandez, L., Voskuyl, A. E., Broens, B., Nejentsev, S., Mirfazeli, E. S. & Ruiter, A. M., 16 Aug 2024, In: Journal of Neurology, Neurosurgery and Psychiatry. 95, 9, p. 855-864 10 p., jnnp-2023-332224.
Research output: Contribution to journal › Article › Academic › peer-review
IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn's disease
Seidelin, J. B., Jensen, S., Hansen, M., de Carvalho Bronze, M. R., Cuchet-Lourenço, D., Nejentsev, S., LaCasse, E. C. & Nielsen, O. H., 1 Mar 2024, In: Clinical and Experimental Immunology. 215, 3, p. 291-301 11 p.
Research output: Contribution to journal › Article › Academic › peer-review
All publications

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Amsterdam institute for Immunology and Infectious diseases

Sergey Nezhentsev

Specialization

Focus of research

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Impact of COVID-19 disease and vaccination on dermatological immune-mediated inflammatory diseases atopic dermatitis, psoriasis, and vitiligo: a Target2B! substudy

T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination

IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn's disease