Specialization
I specialise in RNA biology, translational regulation, and cellular stress responses, with a focus on leukodystrophies such as VWM. My expertise lies in unraveling molecular pathomechanisms and linking these to diagnostic applications and translational pipelines. Together with my team, I have shown how mutations in eIF2B disrupt translational control and glial function. This dual focus on mechanistic discovery and clinical translation positions our research at the interface of fundamental discovery, diagnostics, and therapeutic innovation.
Focus of research
I am a molecular biologist with a strong focus on translational control in the brain. My research aims to unravel the molecular mechanisms underlying leukodystrophies, with particular emphasis on vanishing white matter (VWM). Using disease models and patient-derived material, I have demonstrated that dysregulation of the integrated stress response (ISR) is a key driver of pathology. These insights now underpin preclinical studies and a clinical trial, demonstrating my commitment to connecting fundamental mechanisms with diagnostics and therapeutic strategies. In the coming years, I will expand my research to dissect how altered translational control affects glial function and white matter integrity in other leukodystrophies. Working in close collaboration with clinicians, I ensure that these efforts remain aligned with patient needs and contribute to bridging discovery science with clinical care to improve patient care.