Cancer Center Amsterdam

Alsya Affandi

PhD

Research Associate, CCA - Cancer biology and immunology Research Associate, Molecular cell biology and Immunology

Specialization

Immunology / Dendritic cells / Cancer / Autoimmunity

Focus of research

I am a senior postdoc (NWO Veni laureate) in fundamental and translational immunology with an extensive experience in cancer and autoimmunity research. My research focuses on developing novel therapeutic nanovaccines, by harnessing dendritic cells to drive anti-cancer immune responses or to dampen in autoimmune diseases.

Key publications
Latest publications

Selective tumor antigen vaccine delivery to human CD169⁺ antigen-presenting cells using ganglioside-liposomes
Affandi, A. J., Grabowska, J., Olesek, K., Venegas, M. L., Barbaria, A., Rodríguez, E., Mulder, P. P. G., Pijffers, H. J., Ambrosini, M., Kalay, H., O’Toole, T., Zwart, E. S., Kazemier, G., Nazmi, K., Bikker, F. J., Stöckl, J., van den Eertwegh, A. J. M., de Gruijl, T. D., Storm, G., van Kooyk, Y., & 2 othersden Haan, J. M. M. & O'Toole, T., 3 Nov 2020, In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 117, 44, p. 27528-27539 12 p.
Research output: Contribution to journal › Article › Academic › peer-review
CD169 Defines Activated CD14⁺ Monocytes With Enhanced CD8⁺ T Cell Activation Capacity
Affandi, A. J., Olesek, K., Grabowska, J., Nijen Twilhaar, M. K., Rodríguez, E., Saris, A., Zwart, E. S., Nossent, E. J., Kalay, H., de Kok, M., Kazemier, G., Stöckl, J., van den Eertwegh, A. J. M., de Gruijl, T. D., Garcia-Vallejo, J. J., Storm, G., van Kooyk, Y. & den Haan, J. M. M., 28 Jul 2021, In: Frontiers in immunology. 12, p. 697840 697840.
Research output: Contribution to journal › Article › Academic › peer-review
Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis
Affandi, A. J., Carvalheiro, T., Ottria, A., Broen, J. C. A., Bossini-Castillo, L., Tieland, R. G., Bon, L. V., Chouri, E., Rossato, M., Mertens, J. S., Garcia, S., Pandit, A., de Kroon, L. M. G., Christmann, R. B., Martin, J., van Roon, J. A. G., Radstake, T. R. D. J. & Marut, W., 1 Sept 2019, In: Annals of the rheumatic diseases. 78, 9, p. 1249-1259
Research output: Contribution to journal › Article › Academic › peer-review
All publications

Cancer Center Amsterdam

Alsya Affandi

Specialization

Focus of research

Selective tumor antigen vaccine delivery to human CD169⁺ antigen-presenting cells using ganglioside-liposomes

CD169 Defines Activated CD14⁺ Monocytes With Enhanced CD8⁺ T Cell Activation Capacity

Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis

Spatial immune composition of tumor microenvironment in patients with pancreatic cancer

An Organotypic Human Lymph Node Model Reveals the Importance of Fibroblastic Reticular Cells for Dendritic Cell Function

Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses

Cancer Center Amsterdam

Alsya Affandi

Specialization

Focus of research

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes

CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity

Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis

Spatial immune composition of tumor microenvironment in patients with pancreatic cancer

An Organotypic Human Lymph Node Model Reveals the Importance of Fibroblastic Reticular Cells for Dendritic Cell Function

Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses

Selective tumor antigen vaccine delivery to human CD169⁺ antigen-presenting cells using ganglioside-liposomes

CD169 Defines Activated CD14⁺ Monocytes With Enhanced CD8⁺ T Cell Activation Capacity