Amsterdam Reproduction & Development

Clinical implications of epigenetic changes The research led by professor Marcel Mannens focusses on (epi)genetic changes that lead to disease and/or aberrant development.

Lessons from the past to improve future health: the Dutch famine birth cohort study A disaster created an opportunity to investigate the effects of undernutrition during the earliest stages of human development on later health and wellbeing.

TRIDENT studies: Implementing Non-Invasive Prenatal Testing (NIPT) in the Netherlands Non-invasive prenatal testing (NIPT) for fetal aneuploidy such as Down syndrome has rapidly transformed the global prenatal screening landscape.

Development of machine learning prediction models on long term cognitive and motor outcome of preterm born children Long term outcome prediction in preterm children is impossible or inaccurate. To improve this we develop a prediction model with machine learning techniques.

Patient-tailored Glucocorticoid Treatment to Prevent Bronchopulmonary Dysplasia and Enhance Neurodevelopmental Outcome in Very Preterm Infants Should a very preterm infants be treated with corticosteroids? We aim to develop an innovation prediction model for bronchopulmonary dysplasia.

Causes of twinning in humans What causes women to have twin (or higher-order multiple birth) pregnancies? To answer we need to distinguish between identical and fraternal twin pregnancies.

Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction: A Randomized Clinical Trial Maternal sildenafil to remedy placental insufficiency and extreme fetal growth restriction is ineffective and potentially even harmful.