Cellular & Molecular Mechanisms
Rationale and common goals
The objective of the program Cellular & Molecular Mechanisms is to find causal relationships in brain mechanisms of the healthy brain and the origin of disease. We investigate molecular processes and integrate such processes at higher levels of organization: organelles, cells, networks and the whole brain. In order to treat brain pathologies, it is necessary to improve the understanding of basic brain functions and assess which molecular and physiological mechanisms are involved in those functions. The strength of this theme is its uniform importance for all specific brain disease indications and its links to all other programs. Moreover it includes cutting edge technology and the experts that are needed to implement this.
Key indicators
- Mechanistic research.
- Aiming to elucidate cause and consequence in biological and pathological processes.
- Connecting genome to phenotype.
- Using quantitative as well as qualitative approaches.
Assets
- Top class scientists: top papers, 6 VICIs, 2ERCs, coordinators of large EU projects.
- Cutting edge technology and infrastructure: quantitative proteomics, life cell imaging, FACS, laser capture dissection, brain organoid culture, In utero electroporation, in vivo multi-unit recordings and optogenetics, cellomics, computational modeling.
- Excellent integration of expertise into joint multidisciplinary projects.
- Availability of essential animal models systems.
Translational links
Cellular and Molecular Mechanisms is capable of nurturing all clinical themes in Amsterdam Neuroscience while also maintaining good connections to industry (biotech, pharma), including spin-offs (Sylics BV and Macrobian BV) and also is able to stimulate new initiatives due to its strong scientific and innovative nature.
Making the difference
The essence of this research program is:
- The high quality-driven research with strong team spirit and availability of involved experts on all topics.
- The ability to bridge the gap between genome information and neurobiological processes and behavioral phenotypes.
- The use of cutting edge technology and availability of unique animal models to solve complex questions.
- The implementation of human embryonic stem cell - and patient derived induced pluripotent stem cell (iPSC) strategies in order to generate new models that connect fundamental brain research towards clinical relevant questions.
Program leaders
Taskforce team
Program members
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AB Smit
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Aina Badia Soteras
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Alessandro Moro
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Alicia Sanz Sanz
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Aline Mak
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Amanda M. Legemaat MSc
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Ana Rita Agra de Almeida Quadros
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Andrea Romaguera Alvarez
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Andries Kalsbeek PhD, (Principal Investigator)
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Angelika Mühlebner-Fahrngruber PhD
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Anika Bongaarts MSc
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Annemiek van Berkel
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Ann-Sofie M. E. Schauwvlieghe MD
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Ante Prkic
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Aygul Subkhangulova
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Ayoub Khalil
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Bahar Arik-Yetkin BSc
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Bart M. W. Cornelissen MSc
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Bas J. G. van den Boom
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Biswajit Moharana
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Bonnie Plug
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Bruce R. Boti MSc
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Bwee Poll-The PhD, (Principal Investigator)
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Carien Lansink dr.
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Carlos Fitzsimons dr.
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Chaim Huijser PhD
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Charlene Diepenbroek PhD
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Chaya Rodrigues Pereira
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Christiaan Levelt
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Christian A. Lohmann
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Chun-Xia Yi PhD, (Principal Investigator)
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Clara Van Karnebeek PhD, (Principal Investigator)
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Colin R. Mitchell
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Cyriel Pennartz prof. dr.
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Dan Daj
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Daniël Puntman MSC.
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Daniël Puntman
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Debora Pita Illobre
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Desiree Smith DR.ING.
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Diede Witkamp MSC.
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Dirk Jan Ardesch MSc
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Djai Heyer
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Dnyanada Sahasrabudhe
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Eduard Struys DRS.ING.
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Eleonora Aronica Prof., (Principal Investigator)
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Elias Brandorff
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Eline Mertens
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Elise L. Zwerus
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Elise van Bree
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Ellen Oudejans MSC.
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Els P. M. van Meijel
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Emanuel E. Ramos de Carvalho
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Emma Passchier MSC.
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Emma Passchier
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Enzo M. Scutigliani MSc
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Eric A. J. Reits PhD, (Principal Investigator)
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Erwin A. van Vliet PhD
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Esmeralda K. Bosma MSc
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Esther M. van Duin
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Fernando Cazarez Marquez MSc
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Fiona Murphy
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Fran van Heusden
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FTW Koopmans
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Gerrald Lodewijk
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Guido Meijer
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Hanna Lammertse
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Haryadi Prasetya MEng
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HD Mansvelder
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Ilse M. C. Vogels BEng
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Inge M. E. Dijkstra MEng
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Ingeborg Klaassen PhD, (Principal Investigator)
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Irina V. Milanova MSc
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Irune Guerra San Juan
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Isabell Ehmer MSc
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Ivo G. H. Jansen
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Jackelien G. M. van Scheppingen PhD
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Jan M. Cobben PhD
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Jan van Weering PhD, (Principal Investigator)
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Jasper B. Zantvoord
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Jasper J. Anink
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Jasper Smits
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Jean Pie
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Jeannette Lorteije dr.
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Jessica Classen
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Jessica N. Goedhoop
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Jessie Brunner
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Jian Dong
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Jodie Man
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Johannes van der Voorn DR.
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Jolanda C. Naafs MSc
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Jorge Mejias dr.
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Joris Paul Nassal
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Josse Poppinga
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Jovana Kovacevic
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Judith B. M. Ensink
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Julien Fiorilli
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Jurjen Broeke
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Karen A. Sap PhD
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Karlijne W. Geijtenbeek MSc
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Katinka R. van Kranendonk
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Katy A. van Galen
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Kevin Batenburg
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Kilian M. Treurniet
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Kim Wolzak
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Koen van Lith DRS.
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KW Li
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Lamis Saad
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Lars van der Heide dr.
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Laura A. Tseng
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Laura Bonouvrié DR.
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Laura L. Koekkoek
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Leonie A. Menke PhD
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Leslie Eggels BSc
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Lianne Klaver
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Lianne Scholtens
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Lidewij H. Wolters
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Lola van Linge
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Lucas A. Ramos
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Maaike van Boven
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Maarten Kamermans PhD
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Madeleine J. C. Vader
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Maik Derksen
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Maj B. Holzel
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Maj R. Gigengack
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Manon Kappelhof MD
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Manon L. Tolhuisen MSc
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Mara L. van der Hoeven MSc
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Marc Engelen PhD, (Principal Investigator)
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Marchien G. Dallinga
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Marco Hoekman dr.
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Marianna Bugiani Dr.
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Marieke Meijer DRS.
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Marisa Simas Mendes MSC.
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Marit Lucas
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Marjo van der Knaap PROF.DR., (Principal Investigator)
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Mark Verheijen
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Marta Jorge Oliva
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Marten Smidt prof. dr.
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Martijn van den Heuvel DR., (Principal Investigator)
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Matthias Voss
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Matthijs oude Lohuis
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Matthijs Verhage PROF.DR., (Principal Investigator)
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MCM de Gunst
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Menno Stellingwerff DRS.
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Miao Chen
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Miguel Gonzalez Lozano
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Miriam Öttl
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Mirjam Wamelink DRS.
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Murat Kilicarslan
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Myrtille C. R. Gumbs MSc
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Natalia Goriounova
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Nicole I. Wolf DR.
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Nicole N. van der Wel PhD
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Niels Cornelisse PhD, (Principal Investigator)
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Nikki (Danique Michelle) van Bommel
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Nina L. Fransen
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Nitash Zwaveling-Soonawala PhD
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Nora Runia MSc
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Olvert A. Berkhemer
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Ozlem Engin
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Parand Zarekiani BSc. Psychobiology
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Pascal Bielefeld
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Peter Lauffer MD
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Pieter Roelfsema
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Praneeta R. Konduri
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Priyanka Rao
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Quentin Thomas BOURGEOIS
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Quinty Bisseling
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Ralph R. T. Hamelink
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Rein Hoogstraaten
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Reinder Dorman
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Reinier Bakker MSc
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Reinier Schlingemann PhD, (Principal Investigator)
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René Wilbers
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RFG Toonen
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Rhodé Erbrink
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Rob Ofman BEng
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Rocío Diez Arazola
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Roel de Haan
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Roel J. T. Mocking PhD
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Rory Pijnenburg
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S Spijker
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Sabine Krom PhD
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Sander Groffen DR.IR.
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Saskia M. Maas
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Sebastián E. Loyola Arroyo
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Sehrazat Kavraal
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Shanice Beerepoot
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Siemon de Lange
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Simon Houtman
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Stanley Darma MD
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Stephan Kemp PhD, (Principal Investigator)
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Stephanie I. W. van de Stadt
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Susanne E. la Fleur PhD, (Principal Investigator)
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Sven Kerst MSC.
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Sven Kerst
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Swip Draijer
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Taco Goedemans
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Taranen Arbab MSc
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Tessel M. Boertien MD